Metabolic Activation of Chemical Carcinogens and DNA Adduct Formation

Increased responsiveness to and/or production of growth factors, hormones, and other active molecules 

Decreased responsiveness to inhibitory growth signals Perturbation of intracellular signaling pathways 

Inhibition of terminal differentiation of initiated cells Acceleration of differentiation of uninitiated cells Inhibition of apoptosis in initiated cells 

Toxicity/compensatory hyperplasia Resistance to toxicity by initiated cells 

6 METABOLIC ACTIVATION OF CHEMICAL CARCINOGENS AND DNA ADDUCT FORMATION 

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