C chemokines

Also termed 7-chemokines, C Chemokines are composed of only two cysteines one on the N-terminus and the other a downstream cysteine. There are two chemokines in this group, lymphotactin-a (XCL1) and lymphotactin-(3 (XCL2). Their function is the attraction of T-cell precursors to the thymus. 

Also termed 8-chemokines, CX3C Chemokines are composed of three amino acids between the two cysteines. This subgroup has only one member, fractalkine (CX3CL1). CX3C chemokines are secreted as well as present on the cell surface and serve both as a chemoattractant and as an adhesion molecule. 

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Finally, a new area of research has concentrated on monocyte chemotactic protein-1 (MCP-1), a 76-amino acid peptide that is one of the best-studied members of the C-C chemokine subfamily. Recent human and animal studies indicate that the recruitment of macrophages to the arterial lesion is predom-... 

Hogaboam, C.M. et al., Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2, Am. J. Pathol., 156, 1245, 2000. 

SCY Intercrine alpha family (small cytokine C-X-C) (chemokine CXC) E(M) 0(0) 0(0) 1B2T... 

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K. C. Chemokine receptor-ligand interactions measured using time-resolved fluorescence. Biochemistry 1998, 37, 2372-2377. 

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