Macrophages, human

For neutrophils, several groups have reported alterations in chemotactic activity following exposure to Pb [79,80], As was the case for macrophages, human neutrophils exposed to Pb were suggested to have increased release of ROIs [81]. Therefore, neutrophils may contribute to Pb-induced tissue inflammation and damage via increased ROI release. 

IL-IOR is a single-chain receptor. IL-IOR belongs to the class II cytokine receptor family that also includes the IFN receptors (IFNy and IFNap receptors). The extracellular region consists of two homologous fibronectin type III domains that are without the WSXWS motif characteristic of class I cytokine receptors. It is expressed on B cells, thymocytes, and other cellular lines such as mast cells and macrophages. Human IL-IOR mRNA is restricted mostly to hematopoietic cells and cell lines. ... 

Mammalian defensins 3 P Sttands 3 disulfides Rat, rabbit, guinea pig, human neucrophifs. rabbit alveolar macrophages, human, mouse Paneth cells MCP,NP,HNP,GNCP. rat NP, ciyptidins... 

Saito,Y Higuchi,Y awakami,S Yamashita,F Hashida,M. (2009).Immunostimulatory Characteristics Induced by Linear Polyethyleneimine Plasmid DNA Complexes in Cultured Macrophages, Human Gene Therapy, 20, 137-145. 

Human Immunodeficiency Virus. Human immunodeficiency vims (HIV) causes Acquired Immunodeficiency Syndrome (AIDS), which has no cure. HIV infects the cells of the human immune system, such as T-lymphocytes, monocytes, and macrophages. After a long period of latency and persistent infection, it results in the progressive decline of the immune system, and leads to full-blown AIDS, resulting in death. 

Zaitseva, M., Blauvelt, A., Lee, S., Lapham, C. K., Klaus-Kovtun, V., Mostowski, H., Manischewitz, J., and Golding, H. (1997). Expression and function of CCR5 and CXCR4 on human langerhans cells and macrophages Implications for HIV primary infection. Nature Medicine 3 1369-1375. 

Ullum, H., Lepri, A. C., Victor, J., Aladdin, H., Phillips, A. N., Gerstoft, J., Skinhoj, P., and Pedersen, B. K. (1998). Production of beta-chemokines in human immunodeficiency virus (HIV) infection Evidence that high levels of macrophage in inflammatory protein-1-beta are asociated with a decreased risk of HIV progression. J. Infect. Dis. 177 331-336. 

Leishmania is a disease complex caused by different species of Leishmania. The parasite, which is transmitted to humans by the bite of phlebotomine sandflies, multiplies within human macrophages. There are an estimated 1.5 million cases in approximately 88 countries each year, with 0.5 million patients suffering from the visceral leishmaniasis. 

Expression (Human) Tissues Leukocytes, thymus, spleen, liver, ovary Cells PBLs, neutrophils,T-cells, dendritic cells, mast cells, eosinophils, macrophages, leukocytes Tissues spleen, small intestine, placenta, lung smooth muscle, Cells bronchial smooth muscle, CD34+ hemapoietic progenitor cells, monocytes, macrophages, mast cells, eosinophils, neutrophils, PBLs, human umbilical vein endothelial cells Tissues, heart, skeletal muscle, spleen, brain, lymp node, adrenal medulla, lung, human pumonary/ saphenous vein Cells monocytes, macrophages, mast cells, eosinophils, cardiac muscle, coronary artery, PBLs... 

Tissue-Specific Expression. In adult rodents, PPAR.a is expressed in liver, kidney, intestine, heart, skeletal muscle, retina, adrenal gland, and pancreas. In adult human, PPARa is expressed in the liver, heart, kidney, large intestine, skeletal muscle (mostly slow-twitch oxidative type I fibers), and in cells of atherosclerotic lesions (endothelial cells, smooth muscle cells, and monocytes/macrophages). Therefore, regardless of... 

Tissue-Specific Expression. In the adult rodent, PPARy is expressed in brown and white adipose tissue, and at lower levels in intestine, retina, skeletal muscle, and lymphoid organs. In human, PPARy is most abundantly expressed in white adipose tissue and at lower levels in skeletal muscle, the heart, and liver, but not in lymphoid tissues, although PPARy has been identified in macrophages in human atheromas. 

Cleget, M. Polla, B.S. (1990). Erythrophagocytosis induces heat shock protein synthesis by human monocytes-macrophages. Proc. Natl. Acad. Sci. USA 87, 1081-1085. 

Deeks SG, Lu J, Hoh R, Neilands TB, Beatty G, Huang W, Liegler T, Hunt P, Martin JN, Kuritzkes DR (2007) Interruption of enfuvirtide in HIV-1 infected adults with incomplete viral suppression on an enfuvirtide-based regimen. J Infect Dis 195 387-391 Dejucq N, Simmons G, Clapham PR (2000) T-ceU line adaptation of human immunodeficiency virus type 1 strain SF162 effects on envelope, vpu and macrophage-tropism. J Gen Virol 81 2899-2904... 

A variety of other clinically important infections, such as brucellosis, listeriosis, salmonellosis, and various Mycobacterium infections, are of interest as these are often localized in organs rich in MPS cells. Liposome encapsulation has been demonstrated to improve therapeutic indices of several drugs in a number of infectious models. The natural avidity of macrophages for liposomes can also be exploited in the application of the vesicles as carriers of immunomodulators to activate these cells to an microbicidal, antiviral, or tumoricidal state. These studies were recently reviewed by Emmen and Storm (1987), Popescu et al. (1987), and Alving (1988). In addition to the treatment of "old" infectious diseases, the concept of MPS-directed drug delivery is of considerable interest for the therapy AIDS, possibly enabling control of human immunodeficiency virus replication in human macrophages. 

---