Neurons dorsal root ganglion

Jung H, Toth PT, White FA, Miller RJ (2008) Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem 104 254-263... 

Jung H, Toth PT, White PA, Miller RJ (2008) Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem 104 254-263 Kahn L, Alonso G, Normand E, Manzoni OJ (2005) Repeated morphine treatment alters polysia-lylated neural cell adhesion molecule, glutamate decarboxylase-67 expression and ceU proliferation in the adult rat hippocampus. Em J Nemosci 21 493-500 Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA (2007) HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ (2) 296-305... 

Zhang N, Rogers TJ, Caterina M, Oppenheim JJ (2004) Proinflammatory chemokines, such as C-C chemokine hgand 3, desensitize mu-opioid receptors on dorsal root ganglia neurons. J Immunol 173 594-599... 

Jung, H., Toth, P. T., White, F. A., and Miller, R. J. (2008). Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J. Neurochem. 104, 254—263. Kiguchi, N., Maeda, T., Kobayashi, Y., and Kishioka, S. (2008a). Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice. Neurosci. Lett. 445, 140—143. 

Paradoxically, pyridoxine itself can also cause pathology in the central nervous system consisting of necrosis of dorsal root ganglia neurons and a centrifugal axonal atrophy and breakdown of peripheral and central sensory axons (Xu et al., 1989). This may occur at doses as low as 200-500 mg/d. However, in clinical trials using 100-150 mg/d to treat carpal tunnel syndrome, no toxicity was reported, suggesting that this a safe dose in adults. On the other hand, there are insufficient data to recommend long-term use of pyridoxine in children. 

Donaldson LF, McQueen DS, Seckl JR (1994) Local anaesthesia prevents acute inflammatory changes in neuropeptide messenger RNA expression in rat dorsal root ganglia neurons. Neurosci Lett 175 111-113... 

Melanocortins appear to protect damaged central neurons from neurotoxins, as demonstrated in a model employing unilateral destruction of the substantia nigra. Accelerated denervation sensitivity and increased dopamine immunoreactivity in the substantia nigra account for the melanocortin-induced improvement in motor behavior of these injured rats. Similarly, dorsal root ganglia neurons subjected in vitro to cisplatin toxicity are protected to some degree by the ACTH 4—9 analog. This protection is specific in that it does not extend to Schwann cells or satellite cells, nor does it protect any of these cells from taxol toxicity. 

Olah, Z., Karai, E., and ladarola, M.J. (2001) Anandamide activates vanilloid receptor 1 (VRl) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VRl, J. Biol. Chem., 276 31163-70. Olah, Z., Szabo, T., Karai, L., Hough, C, Fields, R.D., Caudle, R.M., Blumberg, P.M., and ladarola, M.J. (2001) Eigand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1, /. Biol. Chem., 276 11021-30. 

Olah, Z., Karai, L., and ladarola, M.J. (2001) Anandamide activates vanilloid receptor 1 (VRl) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VRl, Journal of Biological Chemistry 276 31163-31170. 

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