Matrix metallo-proteinase

As with UC, the immune activation seen in CD involves the release of many proinflammatory cytokines. Cytokines thought to play major roles in CD are derived from T-helper type 1 cells and include interferon-y, TNF-a, and IL-1, IL-6, and IL-12. TNF-a is a major contributor to the inflammatory process seen in CD. Its physiologic effects include activation of macrophages, procoagulant effects in the vascular endothelium, and increases in production of matrix metallo-proteinases in mucosal cells.9,15 Excessive production of both... 

Okuma T, Terasaki Y, Kaikita K, et al. C-C chemokine receptor 2 (CCR2) deficiency improves bleomycin-induced pulmonary fibrosis by attenuation of both macrophage infiltration and production of macrophage-derived matrix metallo-proteinases. J Pathol 2004 204(5) 594-604. 

In the course of a study of structure-based design and synthesis of a potent matrix metallo-proteinase-13 inhibitor based on a pyrrolidinone scaffold, the Suzuki coupling reaction of a,/ -unsaturated /-lactam iodide (40) with 4-methoxyphenylboronic acid was carried out to give the corresponding coupling product in 77 % yield (Eq. (76)) [119]. 

Paul R, Lorenzl S, Koedel U, Sporer B, Vogel U, Frosch M, Pfister HW (1998) Matrix metallo-proteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Aim Neurol 44 592-600... 

H. D. Foda, S. Zucker, Matrix metallo-proteinases in cancer invasion, metastasis and angiogenesis. Drug Discovery Today 2001, 6, 478-482. 

Enzy. abbrev. cheym, = chymotrypsin memb. = membrane M-met. = macrophage-metallo MMP = matrix metallo-proteinase pI.S = plasminogen PMN = polymorpho-nucleates try. = trypsin. 

Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E. and Seiki, M. (1994). A matrix metallo-proteinase expressed on the surface of invasive tumor cells. Nature 570, 61-65. 

Ikeda U, Shimada K (2003) Matrix metallo-proteinases and coronary artery diseases. Clin Cardiol 26 55-59... 

Nguyen Q, Murphy G, Hughes CE, Mort JS, Roughley PJ. Matrix metallo-proteinases cleave at two distinct sites on human cartilage link protein. Biochem J 1993 295 595-598. 

Y5. Ylisirnio, S., Hoyhtya, M., and Turpeenniemi-Hujanen, T., Serum matrix metallo-proteinases-2, -9, and tissue inhibitors of metalloproteinases-1, -2 in lung cancer— TlMP-1 as a prognostic marker. Anticancer Res. 20, 1311-1316 (2000). 

Lobmann R, Ambrosch A Waldmann K, Schnltz G, Lehnert H, Schiweck S. Expression Matrix-metallo-proteinases and inhibitors in the wonnds of diabetic and non-diabetic patients. Diabetologia 2002 45 1011-1016. 

SELP-815K-MMPRS-6mer SEEP-815Kfused with a matrix-metallo-proteinase sensitive peptide sequence s69 [78]... 

Hydroxamic acids, which have been extensively studied as metalloenzyme inhibitors and have been shown to be potent inhibitors of matrix metallo-proteinases, are a family of zinc-dependent enzymes associated with diseases such as cancer, arthritis and multiple sclerosis. 

Galis ZS, Johnson C, Godin D, et al. Targeted disruption of the matrix metallo-proteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling. Circ Res 2002 91 852-859. 

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