Bleomycin-induced pulmonary fibrosis

Burdick MD, Murray LA, Keane MP, et al. CXCL11 attenuates bleomycin-induced pulmonary fibrosis via inhibition of vascular remodeling. Am J Respir Crit Care Med 2005 171(3) 261-268. 

Yara S, Kawakami K, Kudeken N, et al. FTS reduces bleomycin-induced cytokine and chemokine production and inhibits pulmonary fibrosis in mice. Clin Exp Immunol 2001 124(l) 77-85. 

Okuma T, Terasaki Y, Kaikita K, et al. C-C chemokine receptor 2 (CCR2) deficiency improves bleomycin-induced pulmonary fibrosis by attenuation of both macrophage infiltration and production of macrophage-derived matrix metallo-proteinases. J Pathol 2004 204(5) 594-604. 

Corbel M, Caulet-Maugendre S, Germain N, Molet S, Lagente V, Boichot E. Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat. J Pathol 2001 193(4) 538—545. 

Keane MP, Belperio JA, Burdick MD, Strieter RM. IL-12 attenuates bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2001 281(1) ... 

Kim JH, Kim HY, Kim S, Chung JH, Park WS, Chung DH. Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma. Am J Pathol 2005 167(5) 1231-1241. 

Inayama M, Nishioka Y, Azuma M, et al. A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 2006 173(9) 1016-1022. 

Antioxidant therapy might be promising medication for the treatment of some lung disorders. For example, lecithinized phosphatidylcholine-CuZnSOD suppressed the development of bleomycin-induced pulmonary fibrosis in mice [284] these findings could be of relevance for the treatment of bleomycin-stimulated pulmonary fibrosis in humans. Davis et al. [285] recently demonstrated that the treatment of premature infants with recombinant human CuZnSOD may reduce early pulmonary injury. 

Katsuma, S., Nishi, K., Tanigawara, K., Ikawa, H., Shiojima, S., Takagaki, K., Kamin-ishi, Y., Suzuki, Y., Hirasawa, A., Ohgi, T., Yano, J., Murakami, Y., and Tsujim-oto, G., Molecular monitoring of bleomycin-induced pulmonary fibrosis by cDNA microarray-based gene expression profiling, Biochem. Biophys. Res. Commun., 288, 747-751, 2001. 

Cystostatic antibiotics insert themselves into the DNA double strand this may lead to strand breakage (e.g., with bleomycin). The anthracycline antibiotics daunorubkin and adriamycin (doxorubicin) may induce cardiomyopathy. Bleomycin can also cause pulmonary fibrosis. 

Oxidative stress reduces the rate of cell proliferation, and that occurring during chemotherapy may interfere with the cytotoxic effects of antineoplastic drugs, which depend on rapid proliferation of cancer cells for optimal activity. Antioxidants detoxify ROS and may enhance the anticancer effects of chemotherapy. For some supplements, activities beyond their antioxidant properties, such as inhibition of topoisomerase II or protein tyrosine kinases, may also contribute. ROS cause or contribute to certain side effects that are common to many anticancer drugs, such as gastrointestinal toxicity and muagenesis. ROS also contribute to side effects that occur only with individual agents, such as doxorubicin-induced cardiotoxicity, cisplatin-induced nephrotoxicity, and bleomycin-induced pulmonary fibrosis. Antioxidants can reduce or prevent many of these side effects, and for some supplements the protective effect results from activities other than their antioxidant properties. Certain side effects, however, such as alopecia and myelosuppression, are not prevented... 

Eitzman DT, McCoy RD, Zheng X et al. (1996) Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 97 232-237... 

Cytotoxic antibiotics depress the bone marrow, cause gastrointestinal upsets and stomatitis, alopecia, cardiomyopathy (daunorubicin and doxorubicin) and pulmonary fibrosis and skin rashes (bleomycin). Some of these effects are dose-dependent, for example, doxorubicin-induced cardiomyopathy. Others may be potentiated by concomitant use of radiotherapy. 

Altered expression of small proteoglycans, collagen and TGF/3 has been shown in bleomycin-induced pulmonary fibrosis in rats (Khalil etal., 1989 Shahzeidi etal., 1993 Denholm and Rollins, 1993 Westergren-Thorsson etal.,... 

Chandler, D.B., Hyde, D.M. and Giri, S.N. (1983). Morphometric estimates of infiltrative cellular changes during the development of bleomycin induced pulmonary fibrosis in hamsters. Am. J. Pathol. 112, 170-177. 

Hoyt, D.G. and Lazo, J.S. (1988). Alteration of pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor b precede bleomycin-induced pulmonary fibrosis in mice. J. Pharmacol. Exp. Ther. 246, 765-771. 

Phan, S.H. and Kunkel, S.L. (1986). Inhibition of bleomycin induced pulmonary fibrosis by nordihydroguaiaretic acid. Am. J. Pathol. 124, 343-352. 

Phan, S.H., Thrall, R.S. and Williams, C. (1981). Bleomycin induced pulmonary fibrosis. Effect of steroid on lung collagen metabolism. Am. Rev. Respir. Dis. 124, 428-434. 

Raghow, R., Lurie, S., Seyer, J.M. and Kang, A.H. (1985). Profiles of steady state levels of messenger RNAs coding for type 1 procoUagen, elastin, and fibronectin in hamster lungs undergoing bleomycin-induced interstitial pulmonary fibrosis. J. Clin. Invest. 76, 1733-1739. 

Sendelbach, L.E., Lindenschmidt, R.C. and Witschi, H.P. (1985). The eflfea of cyclosporine A on pulmonary fibrosis induced by butylated hydroxytoluene, bleomycin and beryd-lium sulfate. Toxicol. Lett. 26, 169-173. 

Thrall, R.S., Barton, R.W., D Amato, D.A. and Sulavik, S.B. (1982). Differential cellular analysis of bronchoalveolar lavage fluid obtained at various st es during the development of bleomycin induced pulmonary fibrosis in the rat. Am. Rev. Respir. Dis. 126, 488-492. 

Clark JG, Overton JE, Marino BA, Uitto J, StarcherBC. 1980. Collagen biosynthesis in bleomycin-induced pulmonary fibrosis in hamsters. J. Lab. Clin. Med. 96 943-53... 

Giri SN, Hyde DM, NakashimaJM. 1986. Analysis of bronchoalveolar lavage fluid from bleomycin-induced pulmonary fibrosis in hamsters. Toxicol. Pathol. 14 149-57... 

Wang Q, Giri SN, Hyde DM, Li C. 1991. Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin. Biochem. Pharmacol. 42 1115-22... 

---