Collagen induced arthritis

In addition to antibodies targeting the CD3 subunit of the TCR complex, antibodies against the a and (3 subunits of the TCR have been tested as therapeutic agents. A benefit for the treatment experimental autoimmune encephalomyelitis or collagen induced arthritis could be shown in animal models [8]. 

AIA, adjuvant-induced arthritis CFA, complete Freund s adjuvant CIA, collagen-induced arthritis DTH, delayed-type hypersensitivity LPS, lipopolysaccharide. 

CAIA, collagen Ab-induced arthritis CIA, collagen-induced arthritis SAP, serum amyloid P-component. 

Williams RO, Feldmann M, Maini RN. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci U S A 1992 89(20) 9784—9788. 

Anthony DD, Haqqi TM. Collagen-induced arthritis in mice an animal model to study the pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol 1999 17(2) 240-244. 

Luross JA, Williams NA. The genetic and immunopathological processes underlying collagen-induced arthritis. Immunology 2001 103(4) 407 116. 

Zheng B, Ozen Z, Zhang X, et al. CXCL13 neutralization reduces the severity of collagen-induced arthritis. Arthritis Rheum 2005 52(2) 620-626. 

Bao L, Zhu Y, Zhu J, Lindgren JU. Decreased IgG production but increased MIP-lbeta expression in collagen-induced arthritis in C-C chemokine receptor 5-delicient mice. Cytokine 2005 31(1) 64-71. 

Quinones MP, Estrada CA, Kalkonde Y, et al. The complex role of the chemokine receptor CCR2 in collagen-induced arthritis implications for therapeutic targeting of CCR2 in rheumatoid arthritis. J Mol Med 2005 83(9) 672-681. 

Thornton S, Duwel LE, Boivin GP, Ma Y, Hirsch R. Association of the course of collagen-induced arthritis with distinct patterns of cytokine and chemokine messenger RNA expression. Arthritis Rheum 1999 42(6) 1109-1118. 

Joosten LA, Lubberts E, Helsen MM, et al. Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis. Arthritis Res 1999 1(1) 81—91. 

Bruhl H, Cihak J, Schneider MA, et al. Dual role of CCR2 during initiation and progression of collagen-induced arthritis evidence for regulatory activity of CCR2+ T cells. J Immunol 2004 172(2) 890-898. 

Revesz L, Bollbuck B, Buhl T, et al. Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg Med Chem Lett 2005 15(23) 5160-5164. 

Plater-Zyberk C, Hoogewerf AJ, Proudfoot AE, Power CA, Wells TN. Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice. Immunol Lett 1997 57(1—3) 117—120. 

De Klerck B, Geboes L, Hatse S, et al. Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis. Arthritis Res Ther 2005 7(6) R1208-1220. 

Ogata H, Takeya M, Yoshimura T, Takagi K, Takahashi K. The role of monocyte chemoattractant protein-1 (MCP-1) in the pathogenesis of collagen-induced arthritis in rats. J Pathol 1997 182(1) 106-114. 

Kasama T, Stricter RM, Lukacs NW, Lincoln PM, Burdick MD, Kunkel SL. Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest 1995 95(6) 2868-2876. 

Nanki T, Urasaki Y, Imai T, et al. Inhibition of fractalkine ameliorates murine collagen-induced arthritis. J Immunol 2004 173(11) 7010-7016. 

In vitro TGN1412 caused a profound, polyclonal T-cell proliferation of human peripheral blood mononuclear cells, including those from patients with BCLL. It also induced a profound activation and proliferation of T-cell subsets including CD4+ and CD8+ T cells, naive and memory T cells, and regulatory T cells. TGN1412 was shown to induce a transient, well tolerated expansion of T cells in nonhuman primates treated with TGN1412 and efficacy was demonstrated in a rhesus monkey collagen-induced arthritis model. 

Tada, Y. et al., CD28-deficient mice are highly resistant to collagen-induced arthritis, J. Immunol., 162, 203, 1999. 

Haqqi, T.M. et al., Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea, Proc Natl Acad Sci USA, 96, 4524, 1999. 

Several patents claiming aryl sulfonamides have recently appeared [117-121], In the first, compound 43 was described to be effective in the rat collagen-induced arthritis model when dosed at 100 mpk (s.c., q.d., from day 9-17) [117]. This patent also reported that compound 44 significantly inhibited the number of monocytes recruited following thioglycolate injection in a rat peritonitis model. Two other patent applications describe sulfonamides 45 [120] and 46 [121] as CCR2 antagonists. 

ARRY-438162 was found to be efficacious in a number of animal models of inflammation. For example, in a collagen-induced arthritis model in rats, oral administration of ARRY-438162 at lOmg/kg q.d. significantly inhibited paw swelling which was accompanied by inhibition of cartilage damage in the joint and >80% inhibition of pERK in the tissue from the foot with induced arthritis. 

C. M. Paulos, B. Varghese, W. R. Widmer, G. J. Breur, E. Vlashi, and P. S. Low. Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. Arthritis Res. Then 28 R77 Epub ahead of print (2006). 

Campo, G. M., Avenoso, A., Campo, S., D Ascola, A., Traina, P., and Calatroni, A. (2008). Chondroitin-4-sulphate inhibits NF- translocation and caspase activation in collagen-induced arthritis in mice. Osteoarthr. Cartil. 16,1474-1483. 

The potential benefits of MSC therapy may also be limited in patients suffering from certain disorders, such as arthritis. In a preclinical model of collagen-induced arthritis, it was reported that MSC therapy did not confer any benefit in the treatment of arthritis, indicating a possible contraindication of the therapy [660860]. Although it is not yet known whether such observations would translate into treatment in humans, these data highlight the need to perform careful examinations of the inflammatory environment before considering MSC therapy. 

Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor alpha in collagen-induced arthritis Djouad, F., Fritz, V., Apparailly, F., Louis-Plence, P., Bony, C., Sany, J., Jorgensen, C., Noel, D. (2005). Arthritis Rheum, 52... 

Szabo C, Scott GS, Virag L, Egnaczyk G, Salzman AL, Shanley TP, Hasko G (1998) Suppression of macrophage inflammatory protein (MIP)-lalpha production and collagen-induced arthritis by adenosine receptor agonists. Br J Pharmacol 125(2) 379-387... 

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