Chemokines interleukin

Koch AE, Volin MV, Woods JM, et al. Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid joint. Arthritis Rheum 2001 44(1) 31 40. 

Lukacs NW, Stricter RM, Elner V, Evanoff HL, Burdick MD, Kunkel SL. Production of chemokines, interleukin-8 and monocyte chemoattractant protein-1, during monocyte endothelial cell interactions. Blood 1995 86(7) 2767-2773. 

The N-terminal oxidation approach has been exemplified in several ways, for example in the semisynthesis of a fusion protein by coupling periodate-oxidized (i-lactamase (the N-terminal residue is Thr) to a specially modified single-sulfanyl (i.e., thiol) murine F(ab ) by means of an oxime bond.1"1 Here, in order to emphasize that the fusion constructions can involve nonprotein segments of backbone, we describe the extension of the polypeptide backbone of the chemokine interleukin-8 by PEG chains of various types (linear or branched). This operation was carried out so as to modify the pharmacokinetics of the protein. Scheme 3 gives some examples of the different possibilities involved. 

Dianilino squarates, (V), prepared by Palovich (6) were effective in the treatment of diseases mediated by the chemokine, interleukin-8, and were used in the treating atopic dermatitis resulting in pruritus. 

Roth SJ> Carr MW> Springer TA. C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes. Eur J Immuno 1995 25 3482-8. 

Ishikawa-Mochizuki I, Kitaura M, Baba M et al. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9pl3 and a potential homolog of a CC chemokine encoded by molluscum contagiosum virus. FEES Lett 1999 460 544-548. 

CXCRl is a receptor for the chemokine interleukin-8 (IL-8), a mediator of immune and inflammatory responses. Strategically located in the cell membrane, CXCRl binds to IL-8 with high affinity and subsequently transduces a signal across the membrane bilayer to a G-protein-activated second messenger system. Reserchers describe NMR studies of the interactions between IL-8 and human CXCRl in lipid enviromnents. A combination of solution NMR and solid-state NMR studies of IL-8 in the presence of various constructs of CXCRl enables us to propose a model for the multi-step binding process. ... 

Eckmann, L., Kagnoff, M. F., and Fierer, J. (1993). Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect. Immun. 61, 4569-4574. 

Giovannelli, A., Limatola, C., Ragozzino, D., Mileo, A. M., Ruggieri, A., Ciotti, M. T., Mercanti, D., Santoni, A., and Eusebi, F. (1998). CXC chemokines interleukin-8 (IL-8) and growth-related gene product alpha (GROalpha) modulate Purkinje neuron activity in mouse cerebellum. J. Neuroimmunol. 92, 122-132. 

Singh, A., Kulshreshtha, R., and Mathur, A. (2000). Secretion of the chemokine interleukin-8 during Japanese encephalitis virus infection. J. Med. Microbiol. 49, 607-612. 

Frondosin B 160 (Figure 19.16) is a sesquiterpene that was isolated from the marine sponge Dysidea frondosa in 1997 [80]. This compound exhibits low micromolar inhibitory activity against the inflammatory chemokine interleukin-... 

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