Epithelial neutrophil activating peptide

Koch AE, Volin MV, Woods JM, et al. Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid joint. Arthritis Rheum 2001 44(1) 31 40. 

Arenberg DA, Keane MP, DiGiovine B, et al. Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer. J Clin Invest 1998 I02(3) 465 172. 

Chemokines-connective tissue-activating peptide-III (CTAP-III) Epithelial neutrophil-activating peptide-78 (ENA-78)... 

Ahuja SK, Murphy PM. The CXC chemokines growth-related oncogene (GRO) alpha, GRO beta, GRO gamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. J Biol Chem 1996 271 20545-20550. 

Bronchial Asthma. Figure 2 Mechanisms of bronchial hyperresponsiveness. Toxic products from eosinophils [cationic peptides, reactive oxygen species (ROS)] cause epithelial injury. Nerve endings become easily accessible to mediators from mast cells, eosinophils [eosinophil-derived neurotoxin (EDN)], and neutrophils, and to airborne toxicants such as S02. Activation of nerve endings stimulates effector cells like mucosal glands and airway smooth muscle either directly or by cholinergic reflexes. 

Incubation times of 0.5-1 h are required for detection of mRNA levels (which return to base-line levels by 24 h), and incubation times in excess of 4 h are needed before protein secretion is detected. This transient expression of IL-8 is in contrast to the pattern of production by monocytes, epithelial cells and fibroblasts, which show expression that persists for up to 24 h after stimulation. IL-8 (and related NAP-like peptides) is a powerful neutrophil chemoattractant and, in combination with cytochalasin B, can induce degranulation and activation of the respiratory burst ( 3.5.5). 

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