Apoptosis resveratrol

Apoptosis resveratrol/ Sigma 2000 shikim./platelet aggregation inhibitor T resweratrol OH Polygonum cuspidatum Sieb. Zucc., Polygomaceae, Ang. 

Classic antioxidants, vitamin E, vitamin C, and others can suppress the activation of apoptosis. For example, ascorbic acid prevented cytochrome c release and caspase activation in human leukemia cells exposed to hydrogen peroxide [128], Pretreatment with A -acctylcystcinc, ascorbate, and vitamin E decreased homocysteine thiolactone-induced apoptosis in human promyelocytic leukemia HL-60 cells [129]. Resveratrol protected rat brain mitochondria from anoxia-reoxygenation damage by the inhibition of cytochrome c release and the reduction of superoxide production [130]. However, it should be mentioned that the proapoptotic effect of ascorbate, gallic acid, or epigallocatechin gallate has been shown in the same human promyelocytic leukemia cells [131]. 

Wu ML, Li H, Wu DC, Wang XW, Chen XY, et al. 2005. CYPlAl and CYPIBI expressions in medulloblastoma cells are AhR-independent and have no direct link with resveratrol-induced differentiation and apoptosis. Neurosci Lett 384 33-37. 

Mertens-Talcott SU, Percival SS. Ellagic acid and quercetin interact synergis-tically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett 2005 218(2) 141-151. 

Table 8. Effects of resveratrol on apoptosis Go/Gl, S aad G2/M phase of cell cycle in LLC cells1...

The diet consists of varied ingredients that impart their potential benefits to human health. Potential interaction of resveratrol with other constituents of the diet is worth considering. Resveratrol has been shown to synergize with both quercetin and ellagic acid present in most of our natural products, in the induction of apoptosis in human leukemia cells [Mertens-Talcott and Percival... 

Dorrie J, Gerauer H, Wachter Y, Zunino SJ. 2001. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res 61 4731-4739. 

Fulda S, Debatin KM. 2004. Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res. 64 337-346. 

Jazirehi AR, Bonavida B. 2004. Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin s lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther 3 71-84. 

Kotha A, Sekharam M, Cilenti L, Siddiquee K, Khaled A, Zervos AS, Carter B, Turkson J, Jove R. 2006. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther 5 621-629. 

Martin AR, Villegas I, La Casa C, de la Lastra CA. 2004. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem Pharmacol 67 1399-1410. 

Scarlatti F, Sala G, Somenzi G, Signorelli P, Sacchi N, Ghidoni R. 2003. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J 17 2339-2341. 

Sexton E, Van Themsche C, LeBlanc K, Parent S, Lemoine P, Asselin E. 2006. Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. Mol Cancer 5 45-58. 

She QB, Bode AM, Ma WY, Chen NY, Dong Z. 2001. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res 61 1604-1610. 

Sun C, Hu Y, Liu X, Wu T, Wang Y, He W, Wei W. 2006. Resveratrol downregulates the constitutional activation of nuclear factor-kappaB in multiple myeloma cells, leading to suppression of proliferation and invasion, arrest of cell cycle, and induction of apoptosis. Cancer Genet Cytogenet 165 9-19. 

Figure 15.4 Mechanisms of apoptosis induction by resveratrol. Resveratrol selectively induces apoptosis in various cancer cells in culture by several mechanisms including activation of death receptor-mediated signaling, mitochondria-dependent cytochrome c release and caspase activation, induction of p53 and p53-regulated proapototic genes, activation of MAP kinase-mediated p53 phosphorylation, blockade of Akt-mediated cell survival pathways, and accumulation of intracellular ceramide level.

Other Mechanisms Resveratrol activated caspase-2 and -8, resulting in the activation of downstream caspases, and induced cell death in a death receptor-or mitochondria-independent manner [Mohan et al., 2006]. The induction of apoptosis in HCT-116 (Bax+ / ) cells by resveratrol was mediated via activation of caspase 6 and subsequent degradation of nuclear coat protein lamin A [Lee et al., 2006]. Resveratrol induced a senescence-like growth arrest in HCT-116 cells via ROS-dependent activation of p38 MAP kinase and ATM kinase, and subsequent phosphorylation of p53 and induction of p21WAF1 CIP1 [Heiss et al., 2007]. In contrast, a p53-independent mechanism for resveratrol-induced apoptosis of HCT-116 cells was reported [Mahyar-Roemer et al., 2001, 2002]. 

Lin et al. [2006] demonstrated that resveratrol induced apoptosis in MCF-7 cells by interacting with the (33 domain of a cell surface receptor integrin-aV(33,... 

Ahmad N, Adhami VM, Afaq F, Feyes DK, Mukhtar H. 2001. Resveratrol causes WAF-l/p21-mediated G(l)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin Cancer Res 7 1466-1473. 

Aziz MH, Nihal M, Fu VX, Jarrard DF, Ahmad N. 2006. Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phospha-tidylinositol 3 -kinase/Akt pathway and Bcl-2 family proteins. Mol Cancer Ther 5 1335-1341. 

Cecchinato V, Chiaramonte R, Nizzardo M, Cristofaro B, Basile A, Sherbet GV, Comi P. 2007. Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cells. Biochem Pharmacol 74 1568-1574. 

Clement MV, Hirpara JL, Chawdhury SH, Pervaiz S. 1998. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood 92 996-1002. 

Delmas D, Rebe C, Lacour S, Filomenko R, Athias A, Gambert P, Cherkaoui-Malki M, Jannin B, Dubrez-Daloz L, Latruffe N, Solary E. 2003. Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. J Biol Chem 278 41482-41490. 

Estrov Z, Shishodia S, Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M, Aggarwal BB. 2003. Resveratrol blocks interleukin-1 beta-induced activation of the nuclear transcription factor NF-kB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 102 987-995. 

Garvin S, Ollinger K, Dabrosin C. 2006. Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett 231 113-122. 

Gill C, Walsh SE, Morrissey C, Fitzpatrick JM, Watson RW. 2007. Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms. Prostate 67 1641-1653. 

Huang C, Ma WY, Goranson A, Dong Z. 1999. Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis 20 237-242. 

Hwang JT, Kwak DW, Lin SK, Kim HM, Kim YM, Park OJ. 2007. Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway. Ann N Y Acad Sci 1095 441-448. 

Joe AK, Liu H, Suzui M, Vural ME, Xiao D, Weinstein IB. 2002. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin Cancer Res 8 893-903. 

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