T-cell acute lymphoblastic leukemia

Laver JH, Barredo JC, AmylonM, etal. Effects of cranial radiation in children with high risk T cell acute lymphoblastic leukemia a Pediatric Oncology Group report. Leukemia 2000 14(3) 369-373. 

As an example, at least one of the trials was criticized after a volunteer died following poor clinical practices. In another trial three patients were successfully treated for an x-linked severe combined immunodeficiency disease but 2 years after the treatment two of the patients developed T-cell acute lymphoblast leukemia. The FDA promptly placed a ban on any further similar clinical studies. 

V4. van Dongen, J. J., Quertermous, T., Bartram, C. R., Gold, D. P., Wolvers-Tettero, I. L., Comans-Bitter, W. M., Hooijkaas, H., Adriaansen, H. J., de Klein, A., Raghavachar, A., et al. T cell receptor-CD3 complex during early T cell differentiation. Analysis of immature T cell acute lymphoblastic leukemias (T-ALL) at DNA, RNA, and cell membrane level. J. Immunol. 138, 1260-1269 (1987). 

W2. Weiss, L. M., Bindl, I. M., Picozzi, V. I., Link, M. P., and Warnke, R. A., Lymphoblastic lymphoma An immunophenotype study of 26 cases with comparison to T cell acute lymphoblastic leukemia. Blood 67, 474-478 (1986). 

A fatal case of toxic epidermal necrolysis that involved 90% of the total body surface has been described in a 15-year-old boy with T cell acute lymphoblastic leukemia treated concomitantly with co-trimoxazole and methotrexate (193). 

Indications T-cell acute lymphoblastic leukemia, T-cell lymphoblastic lymphoma Category Antineoplastic Purine analog Half-life 0.5- 3 hours... 

Kitchingman GR, Rovigatti U, Mauer AM, Melvin S, Murphy SB, Stass S. Rearrangement of immunoglobulin heavy chain genes in T cell acute lymphoblastic leukemia. Blood 1985 65 725-9. 

Real PJ, Tosello V, Palomero T et al (2009) y-Secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med 15 50-58... 

Rapid multifluorescent TCRG Vy and Jy typing appbcation to T cell acute lymphoblastic leukemia and to the detection of minor clonal populations. Leukemia, 14, 1143-1152. 

Efferth T, Gillet JP, Sauerbrey A, Bertholet V, de Longueville FO, Remade J, Steinbach D. Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia. Mol Cancer Ther 2006 5 1986-1994. 

Ito E, Honma R, Imai J, Azuma S, Kanno T, Mori S, Yoshie O, Nishio J, Iwasaki H, Yoshida K, Gohda J, Inoue J, Watanabe S, Semba K. A tetraspanin-family protein, T-cell acut lymphoblastic leukemia-associated antigen 1, is induced by the Ewing s sarcoma-Wilms mmor 1 fusion protein of desmoplastic small round cell tumor. Am J Pathol. 2003 163 2165-72. 

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