Biomarkers expression

Stricter RM, Starko KM, Enelow RI, Noth I, Valentine VG. Effects of interferon-gamma lb on biomarker expression in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2004 170(2) 133-140. 

Further research is needed to more effectively assess risks to developing humans. For pharmaceuticals, more information is needed to determine whether an effect on a biomarker from an adult study can be applied to set safe levels in juveniles information on biomarker expression in juveniles is lacking. It is also not known whether juvenile humans are more sensitive to immune system perturbations than adults, although ani-... 

Joe AK, Liu H, Suzui M, Vural ME, Xiao D, Weinstein IB. 2002. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin Cancer Res 8 893-903. 

Tanaka, T., Kojima, T., Suzui, M., and Mori, H., Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid suppressing effects on tumor development and biomarkers expression of colon tumorigenesis. Cancer Res., 53, 3908-... 

Pbase Arrest, Apoptosis, and Changes in Biomarker Expression in Several Human Cancer Cell Lines, Clin. Cancer Res. 8, 893-903. 

CASE STUDY FULLY AUTOMATED IMAGE ANALYSIS OF PODOCYTE INJURY BIOMARKER EXPRESSION IN RATS... 

Multiple patient factors may impact biomarker expression. For example, hydration status, medication, diet, tobacco use, exercise, concomitant diseases, or comorbidities may confound interpretation of biomarker values. For tissue biopsies, anesthetic agents and tissue ischania should be considered. Capturing this type of information at the time of sample collections may aid in identification of patient-related confounding factors that inflnence biomarker valnes and interpretation. 

Related investigations include proteomic analysis of lymph [110], study of serum protein profiles in hemodialysis patients [111], a variety of applications in hematology [112-115], detection of multiple variants of serum amyloid alpha in renal cancer [116], search for biomarkers expressed by human pluripotent stem cells... 

Hayman, M.W. and Przyborski, S.A., Proteomic identification of biomarkers expressed by human pluripotent stem cells. Biochem. Biophys. Res. Commun., 316, 918-923 (2004). 

Weigum, S.E., et al., 2007. Cell-based sensor for analysis of EGER biomarker expression in oral cancer. Lab Chip 7 (8), 995-1003. Available at http //pubs.rsc.org/en/content/ articlehtml/2007/lc/b703918b. 

Figure 4.19 Top Synthesis of a monoclonal antibody decorated with luminescent lanthanide chelates. Bottom Specific detection of a biomarker expressed by a cell. Adapted with permission from [12]. Copyright 2010, American Chemical Society...

Figure 4.20 Principle of the dual immunohistochemical detection of biomarkers expressed by human breast cancer cells. Abl = anti-human ER mouse mAb Ab2 = polyclonal rabbit antihuman c-erbB-2 oncoprotein Ab. EuBl and TbB2 see text. Reproduced with permission from [170]. Royal Society of Chemistry...

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