Human tumor cells

Migrastatin (192) (Scheme 37) is a novel macrolide natural product that displays an inhibitory effect on the migration of human tumor cells. After an RCM-based synthesis of the 14-membered macrolide core of 192 [94], Danishefsky also achieved the first total synthesis of the natural compound [95], using the fully functionalized tetraene 191 as the metathesis precursor. Under the conditions shown in Scheme 37, the ring-closing step proceeded (E)-selectively with exclusive participation of the two terminal double bonds in 191, delivering only the ( , ,Z)-trienyl arrangement present in 192. 

Pulciani S, Santos E, Lauver AV, et al. 1982b. Oncogenes in human tumor cell lines. Molecular cloning of a transforming gene from human bladder carcinoma cells. Proc Natl Acad Sci USA 79 2845-2849. 

Some of the [Au(N,0)Cl2] derivatives, namely 58a, 59a and 59b, which have been tested for cytotoxic activity against various human tumor cell lines, have shown significant effects [144]. Compound 57 is a potential alternative to dimethylgold (III) P diketonates and can be used as a starting material for gold coatings by the CVD method [140]. Recent studies have shown that the long-term stability of these... 

A massive body of evidence has already been presented clearly indicating that the medicinal plants of the Pacific Rim elaborate a broad array of cytotoxic substances. Most of these have been characterized using experimental procedures designed to examine the cytotoxicity of natural products against human tumor cell lines. These procedures involve in vitro screening where the viability of cultured cells after exposure to an extract or a purified substance is measured. 

Palozza, P., Serini, S., Torsello, A. et al. 2003a. Mechanism of activation of caspase cascade during beta-carotene-induced apoptosis in human tumor cells. Nutr Cancer 47 76-87. 

UGS1025A, a novel pentacyclic polyketide with an unprecedented furopyrrolizidine skeleton, 46 (Table 4) isolated from the fungus Acremorium sp. KY4917 exhibited antimicrobial and antiproliferative activity against human tumor cell lines. 

Two new polycyclic pyridoacridine alkaloids, arnoamine B, 289, and its demethylated analogue, arnoamine A, have been isolated from the ascidian Cystodytes sp. These new compounds are the first known examples of pyrroles fused to pyridoacridines, have antifungal properties, and are cytotoxic in several human tumor cell lines <1998JOC1657>. Both these compounds have been synthesized, starting from the hydrazone 290 with a Fischer indole synthesis (Scheme 73) <2000JOC5476>. 

Fogh, J., J. M. Fogh, and T. Orfeo. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice, J. Natl. Cancer Inst. 1977, 59, 221-226... 

MacLeod RA, Dirks WG, Matsuo Y, Kaufmann M, Milch H, Drexler HG. Widespread intraspecies cross-contamination of human tumor cell lines arising at source. Int. J. Cancer 1999 83 555-563. 

Misawa, J., Moriwaki, S.I., Kohno, E., Hirano, T., Tokura, Y., Takigawa, M. (2005) The role of low-density lipoprotein receptors in sensitivity to killing by Photofrin-mediated photodynamic therapy in cultured human tumor cell lines. J. Dermatol. Sci. July 20. 

Seeram NP, Adams LS, Hardy ML and Heber D. 2004. Total cranberry extract versus its phytochemical constituents antiproliferative and synergistic effects against human tumor cell lines. J Agric Food Chem 52(9) 2512-2517. 

Harker, W.G., et al., Human tumor cell line resistance to chemotherapeutic agents does not predict resistance to natural killer or lymphokine-activated killer cell-mediated cytolysis, Cancer. Res. 50, 18, 5931, 1990. 

Figure 29) was tested in several cell lines in a one-dose in vitro primary cytotoxicity assay, and passed the criteria for activity (20-29% growth percentages) next, it was scheduled for evaluation against the full panel of 60 human tumor cell lines at minimum of five concentrations at 10-fold dilution, showing very favorable cytotoxicity <2003EJM781>. 

S. K., Monoclonal antibodies and synthetic peptides as inhibitors of human tumor cell migration. Cancer Res. 50, 4485-4496 (1990). 

Fogh J and Trempe G (1975) New human tumor cell lines. In Fogh J (ed.) Human Tumor Cells In Vitro. Plenum Press, New York, pp.l 15-159. 

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