Resveratrol sensitivity

Gill C, Walsh SE, Morrissey C, Fitzpatrick JM, Watson RW. 2007. Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms. Prostate 67 1641-1653. 

Ivanov VN, Partridge MA, Johnson GE, Huang SX, Zhou H, Hei TK. 2008. Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp Cell Res 314 1163-1176. 

Scarlatti F, Sala G, Ricci C, Maioli C, Milani F, Minella M, Botturi M, Ghidoni R. 2007. Resveratrol sensitization of DU145 prostate cancer cells to ionizing radiation is associated to ceramide increase. Cancer Lett 253 124-130. 

Duraj J, Bodo J, Sulikova M, Rauko P, Sedlak J (2006) Diverse resveratrol sensitization to apoptosis induced by anticancer dmgs in sensitive and resistant leukemia cells. Neoplasma 53 384-392... 

Recently, resveratrol was found to reverse fat-induced insulin resistance [McCarty, 2005]. This observation provides more enthusiasm for researchers to use resveratrol as an antidiabetic agent. Su and associates [2006] showed that resveratrol significantly reduced the plasma glucose concentration as well as the dramatic reduction of triglyceride concentration in streptozotocin (STZ)-induced diabetic mellitus rats in 14 days treatment. They concluded from this observation that resveratrol possesses hypoglycemic and hypolipidemic properties [Su et al., 2006]. Baur et al., [2006] added more value to this conclusion by showing that resveratrol increases insulin sensitivity by lowering the blood... 

Fulda S, Debatin KM. 2004. Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res. 64 337-346. 

Jazirehi AR, Bonavida B. 2004. Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin s lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther 3 71-84. 

Pezet R, Gindro K, Viret O, Spring J-L. 2004. Glycosylation and oxidative dimerization of resveratrol are respectively associated to sensitivity and resistance of grapevine cultivars to downy mildew. Physiol Molec Plant Pathol 65 297-303. 

Gallo, R., Viglizzo, G., Vecchio, F., and Parodi, A., Allergic contact dermatitis from pentylene glycol in an emollient cream, with possible co-sensitization to resveratrol, Contact Dermatitis, 48, 176, 2003. 

In addition, stilbenes are fluorescent compounds which are easily detected by flu-orometry. For resveratrol, fluorescence detection is highly selective and even twice as sensitive as UV detection (Stecher et al. 2001). Due to this potential, methods by using HPLC coupled with absorbance and fluorescence detection were developed (Jeandet et al. 1997 Vitrac et al. 2002). Otherwise identification of stilbenes in wine by HPLC-DAD can be limited by coelution of two or more compounds. Therefore application of modern mass-spectrometry techniques is important to confirm the structure of stilbenes and to detect novel compounds in wine (Monagas et al. 2005b Buiarelli et al. 2007 Careri et al. 2004 Jean-Denis et al. 2006 Kammerer et al. 2004 Mark et al. 2005 Piissa et al. 2006 Stecher et al. 2001). Table 9C. 1 shows an overview on stilbenoid molecular ions and fragments identified in wine and grapevine by mass spectrometry. 

To investigate the probable health benefits of flavonoids and stilbenes in red wine, a RP HPLC method with enhanced separation efficiency, selectivity, sensitivity, and speed has been established for the determination of the flavonols quercetin, myricetin, and kaempferol and the stilbenes cis- and trany-resveratrol in a single The... 

Polyphenols in red wine inhibit cell proliferation in both hormone-sensitive (MCF-7 and T47D) and hormone-resistant breast cancer cell lines (MDA-MB-231). The author suggested that inhibitory effect was partly due to the antioxidant action of resveratrol. 

Resveratrol (grape, red wine) HL-60 human leukemia cell line, SHEP neuroblastoma cells Release of cytochrome c from mitochondria, activation of caspases, induction of p53-dependent transcriptional activation sensitizes TRAIL-induced apoptosis decreases in survivin, increases in Smac/DIABLO [155,156]... 

Trau -resveratrol is added to several dietary supplements with the assumption that it will have the beneficial effects of red wine. This assumption has not yet been tested scientifically. Grape and wine are very complicated mixtures of chemicals, so other compounds, thus far unknown, may also be highly significant. Individual differences in human life styles may add a large amount of deviation to any observations. Resveratrol is sensitive to oxidation in capsules, its aetual amount may be much lower than the label says. In such a concentrate, resveratrol is not protected from oxidation by other components present in red wine. 

The mechanism of action of resveratrol in imatinib-sensitive (IM-S) and -resistant (IM-R) CML cell lines was investigated [58]. Resveratrol induced the loss of viability and apoptosis in IM-S and IM-R in a time- and dose-dependent fashion. Inhibition of... 

The study [83] investigated whether resveratrol can improve nonalcoholic fatty liver disease (NAFLD) and evaluated the possible mechanism. Rats fed a high-fat diet were treated with resveratrol and the liver histology was observed. Hyperinsulinemic euglycemic clamp was performed to assess insulin sensitivity. Fat accumulation was induced in FIepG2 cells, and the cells were treated with RSV. AMP-activated protein kinase phosphorylation levels were detected both in the animal study and cell study. Rats fed a high-fat diet developed abdominal obesity, NAFLD, and insulin resistance, which were markedly improved by 10 week. 

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