Polygonum cuspidatum

Apoptosis resveratrol/ Sigma 2000 shikim./platelet aggregation inhibitor T resweratrol OH Polygonum cuspidatum Sieb. Zucc., Polygomaceae, Ang. 

Polygonum cuspidatum Siebold Zucc. Hu Chang (J apanese knotweed) (stem, root) Polygonin, glucofragulin, emodin, polydatin, flavonoids.33 Treat hypercholesterol. 

Clerodendrum cyrtophyllum, Isatis indigotica, I. oblongata Corchorus olitorius Polygonum cuspidatum Dolichos lablab... 

Studies on the antifungal substance of crude drugs (II). On the roots of Polygonum cuspidatum Sieb.et Zucc. (Polygonaceae). Shouyakugaku Zasshi, 1981, 35, 58-64. 

Arichi, S. Effects of stilbene componets of the roots of Polygonum cuspidatum Sieb. Et. Zucc. On lipid metabolism. Chem. Pharm. Bull. 1982, 30, 1766-1770. 

Vastano BC, Chen Y, Zhu N, Ho C-T, Zhou Z, Rosen RT. 2000. Isolation and identification of stilbenes in two varieties of Polygonum cuspidatum. J Agric Food Chem 48 253-256. 

Polygonum cuspidatum, a weed used in Chinese and Japanese medicine, is one of the first plants identified to extract resveratrol and is one of the richest... 

Keiller DR, Holmes MG (2001) Effects of long-term exposure to elevated UV-B radiation on the photosynthetic performance of five broad-leaved tree species. Photosynth Res 67 229-240 Kogami H, Hanba YT, Kibe T, Terashima I, Masuzawa T (2001) C02 transfer conductance, leaf structure and carbon isotope composition of Polygonum cuspidatum leaves from low and high altitudes. Plant Cell Environ 24 529-538... 

Ventilago calyculata, Rhamnusfrangula (Rhamnaceae), lichen glycosides in Rheum moorcroftianum, Polygonum cuspidatum (Polygonaceae),... 

Kimura, Y. and Okuda, H., Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-hearing mice, J. Nutr., 131, 1844—1849, 2001. 

Emodin (l,6,8-trihydroxy-3-methylanthraquinone), the active principle of Polygonum cuspidatum (Polygonaceae), was reported to be an inhibitor of the p56 -PTK activity from bovine thymus, with an IC50 of 18.5 pM. When the hydroxyl functions at C-6 or C-8 were blocked by methylation or glycosylation, respectively, the effect disappeared. The inhibition was competitive with respect to ATP and non competitive with respect to the substrate [64]. In a bioassay-guided separation of the anthraquinones found in rhizomes of another Polygonaceae species, rhubarb Rheum... 

Some simple stilbenes isolated from the roots of Polygonum cuspidatum (Polygonaceae) showed moderate inhibitory activity of the bovine thymus P56 " tyrosine kinase activity, when angiotensin 1 was used as a substrate. The most potent were resveratrol (26) and its cis form obtained by photochemical isomerisation. Both compounds showed similar potency against rat brain PKC, whereas resveratrol monoglucosides were less active [81]. 

Trans-resveratrol (43) extract prepared from Polygonum cuspidatum (Polygonaceae) showed reduction of reperfusion-induced ventricular fibrillation in vitro) from its control value of 83% to 75% when rats were orally treated with 50mg/kg and lOOmg/kg dose. Thus, it can be a potential alternative to conventional HRT for cardioprotection and osteoporosis prevention [38]. 

Maximol A (528) which had earlier been synthesized from the roots of Rheum maximowiczii, has now been confirmed as a natural product [241 and references therein]. Two dimeric stilbene glucosides (531, 532) have been isolated from the root of Polygonum cuspidatum. Compound 532... 

---