Human promyelocytic leukemia

An extract from Lactuca indica showed significant free radical scavenging activity, and protected phixl74 supercoiled DNA against strand cleavage and reduced oxidative stress in human promyelocytic leukemia HL-60 cells. On account of protocatechulic acid, methyl p-hydroxybenzoate, caffeic acid, 3,5-dicaffeoylquinic acid, luteolin 7-O-fT glucopyranoside, and quercetin 3-0-(3-g 1 ucopyranoside are the major antioxidative constituents (111). 

Martelli AM, Bortul R, Bareggi R, et al. The pro-apoptotic drug camptothecin stimulates phospholipase D activity and diacylglycerol production in the nucleus of HL-60 human promyelocytic leukemia cells. Cancer Res 1999 59 3961-3967. 

Nakatani N, Ichimaru M, Moriyasu M, Kato A. Induction of apoptosis in human promyelocytic leukemia cell line HL-60 by C-benzylated dihydrochalcones, uvaretin, isouvaretin and diuvaretin. Biol Pharm Bull 2005 28 83-86. 

Nara, E., H. Hayashi, M. Kotake, K. Miyashita, and A. Nagao. 2001. Acyclic carotenoids and their oxidation mixtures inhibit the growth of HL-60 human promyelocytic leukemia cells. Nutr Cancer 39(2) 273-283. 

Liu, Y., Chang, R.L., Cui, X.X., Newmark, H.L. and Conney, A.H. 1997. Synergistic effects of curcumin on all-trans retinoic acid- and 1 alpha,25-dihydroxyvitamin D3-induced differentiation in human promyelocytic leukemia HL-60 cells. Oncol Res 9 19-29. 

HETE, 12-hydroxyeicosatetraenoic acid HL60, human promyelocytic leukemia cells... 

Classic antioxidants, vitamin E, vitamin C, and others can suppress the activation of apoptosis. For example, ascorbic acid prevented cytochrome c release and caspase activation in human leukemia cells exposed to hydrogen peroxide [128], Pretreatment with A -acctylcystcinc, ascorbate, and vitamin E decreased homocysteine thiolactone-induced apoptosis in human promyelocytic leukemia HL-60 cells [129]. Resveratrol protected rat brain mitochondria from anoxia-reoxygenation damage by the inhibition of cytochrome c release and the reduction of superoxide production [130]. However, it should be mentioned that the proapoptotic effect of ascorbate, gallic acid, or epigallocatechin gallate has been shown in the same human promyelocytic leukemia cells [131]. 

Nauseef, W. M. (1986). Myeloperoxidase biosynthesis by a human promyelocytic leukemia cell line Insight into myeloperoxidase deficiency. Blood 67,865-72. 

Seo HJ, Surh YJ. (2001) Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. Mutat Res 496 191-198. 

Hayakawa Y, Nakagawa M, Kawai H, Tanabe K, Nakayama H, Shimazu A, Seto H, Otake N. (1983) Studies on the differentiation inducers of myeloid leukemic cells 111. Spicamycin, a new inducer of differentiation of HL-60 human promyelocytic leukemia cells. J Antibiot 36 934-937. 

Grant S, Turner A, Bartimole TM, Nelms P, Joe VC, Jarvis WD (1994) Modulation of l-p-D-arabinofiiranosylcytosine-induced apoptosis in human promyelocytic leukemia cells by staurosporine and other inhibitors of protein kinase C. Oncol Res 6 87-99... 

Tochisawa, K. (1997). Effect of docosahexaenoic acid containing phospholipids on HL-60 human promyelocytic leukemia cell differentiation and their mechanism involved. "A master s thesis submitted to the graduate school of fisheries sciences, Hokkaido University", pp. 1-136. 

Tochisawa, K., Hosokawa, M., Kohno, H., Odashima, S., and Takahashi, K. (1997). Effect of phospholipids containing docosahexaenoic acid on differentiation and growth of HL-60 human promyelocytic leukemia cells. J. Jpn. Oil Chem. Soc. 46, 383-390. 

Jarvis, W.D., Turner, A.J., Povirk, L.F., Traylor, R.S., and Grant, S., Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C, Cancer Res., 54, 1707, 1994. 

As discussed in the previous sections, a number of triterpenoids with great structural diversity have antitumor-promoting activities. In contrast, 28-deacetylbelamcandal (288), a spiroiridal-type triterpenoid, has recently been reported to possess tumor promoting activity [92]. Compound 288, which stimulated differentiation of human promyelocytic leukemia (HL-60) cells (a fast method for screening TPA-type tumor promoters),... 

Chang, Y.C., Huang, H.P, Hsu J.D., Yang, S.F., and Wang, C.J., Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells, Toxicol. Appl. Pharmacol., 205, 201-212, 2005. 

The polyphenol extract from the barley bran (BPE) induced the differentiation of human promyelocytic leukemia HL-60 cells, based on the expression of the differentiation markers such as nitro blue tetrazolium (NBT) reducing activity and a-naphthyl butyrate esterase activity. Prodelphini-din B-3, Tl, T2, and T3 induced 26-40% NBT-positive cells and 22-32% a-naphthyl butyrate esterase-positive cells. Proanthocyanidins might potentiate the retinoic acid (all-frarcs-retinoic acid)-induced granulocytic differentiation and sodium butyrate-induced monocytic differentiation in the HL-60 cells [101]. 

MK-2 did not induce internucleosomal DNA fragmentation in the human promyelocytic leukemia HL-60 and squamous cell carcinoma HSC-4 cell lines. GG induced internucleosomal DNA fragmentation marginally in the HL-60 cells, but to a lower extent than actinomycin D (positive control). However, GG did not induce DNA fragmentation in the HSC-4 cells (Fig. 10). 

Further, eleven 4-phenyl-3,5-diacetyl-1,4-DHPs substituted at the C-4 phenyl ring were synthesized and compared for their cytotoxic activity and MDR reversing activity in in vitro assay systems. Among them, compound G7 (68) showed the highest cytotoxic activity against human promyelocytic leukemia HL-60 and human squamous cell carcinoma HSC-2 cells. However, no compounds tested produced radicals at pH 7.4-12.5. The activity of Pgp... 

Enzyme activity was assayed in the high speed supernate obtained from rat livers homogenized in 50 mM potassium phosphate buffer (pH 7.4) containing 0.1 M NaCI. It was also shown to be applicable to extracts from human promyelocytic leukemia HL-60 cells, and mouse embryo fibroblasts. 

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