Antifungal topical cream

Antifungal topical preparations Butenafine, 1% (cream) apply to affected areas once daily Lotrimin Ultra Effective for the treatment of tinea pedis (athlete s foot), tinea cruris (jock itch), and tinea corporis (ringworm). Clotrimazole and miconazole also effective against Candida albicans. Clinicians should be aware that products carrying the same brand name do not... 

Tea tree oil comes from an evergreen tree native to Australia. The herb has been used as a nonirritating, antimicrobial for cuts stings wounds burns and acne. It can be found in shampoos soaps and lotions. Tea tree oil should not be ingested orally but is effective when used topically for minor cuts and stings. Tea tree oil is used as an antifungal to relieve and control the symptoms of tinea pedis Topical application is most effective when used in a cream with at least 10% tea tree oil. Several commercially prepared ointments are available. The cream is applied to affected areas twice daily for several weeks... 

Silver and its compounds have long been used as antimicrobial agents in medicine. The mechanisms of silver toxicity as they relate to human exposure to pharmaceuticals have been reviewed (328). Silver is active at low concentrations and has a low toxicity. The practice of instilling the eyes of infants with 1% of AgN03 solution immediately after birth is still common in some countries, for prevention of opthalmia neonatorum (329). Silver sulfadiazine 77 is clinically used as a topical antimicrobial and antifungal agent and applied as a cream to prevent bacterial infections in cases of severe burns. It is an insoluble polymeric compound and releases Ag(I) ions slowly. 

Tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis, tinea versicolor, tinea rubrum Action Antifungal antibiotic cellular depletion of essential substrates /or ions Dose Adults Peds >10 y. Massage into affected area bid Onychomycosis Apply to nails daily, w/ removal q7d Caution [B, ] Contra Component sensitivity Disp Cream, gel, topical susp, shampoo, nail lacquer SE Pruritus, local irritation, burning Interactions None noted EMS None OD Not likely, no info available if large amt ingested... 

Uses Candidiasis tinea Infxns Action Antifungal alters cell wall permeability Dose PO Prophylaxis One troche dissolved in mouth tid Rx 1 troche dissolved in mouth 5 x d for 14 d Vag 1% cream 1 applicator full hs for 7 d 2% cream 1 applicator full hs for 3 d Tabs 100 mg vaginally hs for 7 d or 200 mg (2 tabs) vaginally hs for 3 d or 500-mg tabs vaginally hs once Topical Apply bid 10—14 d Caution [B, (C if PO), ] Not for systemic fungal Infxn Contra Component allergy Disp Cream, soln, lotion, vag tabs, vag cream SE Topical Local irritation PO N/V Interactions T Effects OF cyclosporine, tacrolimus X- effects OF spermicides EMS None OD Unlikely... 

Nystatin is a mixture of tetraene antifungals produced by cultures of Streptomyces noursei. The principal component is nystatin Ai (Figure 3.68), but the commercial material also contains nystatin A2 and A3, which have additional glycoside residues. Nystatin is too toxic for intravenous use, but has value for oral treatment of intestinal candidiasis, as lozenges for oral infections, and as creams for topical control of Candida species. 

Naftitine is one of a series of aUylamine antifungal agents, derived from heterocychc spironaphthalenes. It is usually sold in the form of a 1% cream for topical treatment of dermatomycoses, dermatophytes, and yeasts. It is claimed to be more effective than the imidazoles. Local irritation and a burning sensation, if they occur, are only mild (SED-12, 684) (28), (SEDA-16, 297). 

Topical 2% povidone iodine solution and 0.2% chlorhexidine gluconate solution have broad antimicrobial profiles and may be used as cheap spectrum and effective antifungal agents in equine ketomycosis, particularly where Fusarium spp. are involved. A1% dermatological cream formulation of silver sulfadiazine has both antifungal and antibacterial properties and is reasonably well tolerated topically in the horse eye. Its use is advocated where cost restraints exist or for prophylaxis in comeal injuries involving embedded plant material (Hamor Whelan 1999). 

Tolnaftate is a synthetic antifungal agent with a narrow spectrum of activity which is limited to dermatophytes (Epidermophyton, Microsporum and Trichophyton spp.). It could be used to treat mild localized dermatophytic infection. For topical application to dogs, tolnaftate is formulated as a 1% cream containing both polyethylene glycol and propylene glycol. The powder aerosol preparation is less likely to be effective for treatment, but could be applied to prevent spread of the infection. 

The cream 1% contains the synthetic, broad-spectrum, antifungal agent naftifine hydrochloride. It is for topical use only. The chemical name is (E)-N-Cinnamyl-N-methyl-l-naphthalenemethyl-amine hydrochloride. Naftifine hydrochloride has an empirical formula of C21H21N HC1 and a molecular weight of 323.86. The active ingredient... 

The cream and lotion formulations contain the antifungal active compound oxiconazole nitrate. Both formulations are for topical dermatologic use only. The cream contains 10 mg oxiconazole per gram of cream in a white to off-white, opaque cream base of purified water USP, white petrolatum USP, stearyl alcohol NF, propylene glycol USP, polysorbate 60 NF, and cetyl alcohol NF, with benzoic... 

Clotrimazole, an antifungal agent, is used only topically and is available as a 1% cream, lotion, or solution (Lotrimin and Mycelex), as a 1% vaginal cream, as 100-mg or 500-mg vaginal tablets (Gyne-Lotrimin, Mycelex-G), and as 10-mg troches (Mycelex). 

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