Vaginal tablet

Tablets, vaginal 25 meg estradiol (equivalent to 25.8 meg hemihydrate) Rx) Vagifem (Novo Nordisk)...

Oral 0.5, 1, 2 mg tablets Vaginal 0.1 mg/g cream Estradiol transdermal (Estraderm, others)... 

Oral 0.625, 1.25, 2.5, 5 mg tablets Vaginal 1.5 mg/g cream base Ethinyl estradiol (Estinyl)... 

Included in the FDA Inactive Ingredients Guide (oral capsules, suspensions, and tablets vaginal preparations). Included in nonparenteral medicines licensed in the UK. 

Estrogens arc commercially available in a wide variety of dosage fonns oral tablets, vaginal creanrs and foams, irans-demial patches, and iniromascular dosage preparations. 

I = injection T = tablet C = cream Tr = transdermal, continuous delivery, P = parenteral VC = vaginal cream VS = vaginal suppositories Ca = capsule. 

Amphotericin B. Amphotericin B (3), an important polyene antibiotic, is administered almost exclusively via the intravenous route and is therefore discussed in more detail under the systemic antimycotics. The vaginal tablets contain 50 mg amphotericin B, and 100 mg tetracycline base per tablet (see also Antibiotics, tetracyclines). The tablets for oral use contain 50 mg amphotericin B, 250 mg tetracycline base, and 125 mg sodium hexametaphosphate. A combination ointment contains 1 mg fludrocortisone acetate, 2.5 mg neomycin, 0.25 mg gramicidin, and 1 g plastibase in addition to 30 mg amphotericin B (see also Antibiotics, peptides). 

In the last several decades, physical properties of vaginal contraceptive formulations have been improved to deUver spermicide more effectively and enhance consumer compliance. The formulation that deUvers the spermicide can affect the efficacy of vaginal contraceptives (86,87). Formulations currentiy available include jeUies, creams, suppositories, aerosol foams, and foaming tablets. Each consists of a relative inert base material that serves as a carrier for the chemically active spermicide and blocks to some extent the passage of sperm. 

Miconazole If the drug (cream or tablet) is administered vaginally, insert the drug high in the vagina using tiie applicator provided with the product. 

Gyne-Lotrimin) 1 00-mg vaginal tablet daily for 7 days ... 

Vaginal tablet Estradiol (Vagifem ) 1 tablet 2 times/week... 

Avoid systemic (parenteral, oral, TD) vaginal tablet, cream, intravaginal ring Estradiol 25 meg vaginal tablets (insert one PV daily x 14 days, then one PV twice weekly)... 

Egawa et al. [103] by using a microbial assay method reported that miconazole was not detected in the blood after human subjects were given 100 mg tablets of miconazole intravaginally for 14 days. Six species of 12 strains of human vaginal Lactobacillus were insensitive to miconazole. 

Conventional vaginal delivery systems include tablets, foams gels, suspensions, and pessaries. Mucoadhesive gel formulations based on polycarbophil have been reported to remain 3 to 4 days at the vaginal tissue, providing an excellent vehicle for the delivery of progesterone and nonoxynol-9 [66]. 

The inclusion of the a routine microbial limit test in a marketed product stability protocol depends on the pharmaceutical dosage form. Typically, the test would be used only for nonsterile products, especially oral liquids, nasal sprays, and topical liquids, lotions, and creams that have sufficient water activity to support the growth of microorganisms. In contrast, tablets, powder- and liquid-filled capsules, topical ointments, vaginal and rectal suppositories, nonaqueous liquids and inhalation aerosols with a water activity too low to allow for the product to support the growth of microorganisms would not be routinely tested. 

Vaginal Local or systemic effects (hormones) No first-pass metabolism Inconvenient Erratic absorption Irritation Creams, ointments, foams, tablets, pessaries... 

Maintenance dose - 1 tablet inserted vaginally twice weekly. 

Switching from a combination oral contraceptive Insert the contraceptive vaginal ring anytime within 7 days after the last combined (estrogen plus progestin) oral contraceptive tablet and no later than the day that a new cycle of pills would have started. No backup method is needed. 

Combination Pack Vaginal tablet 100 mg and vaginal cream 1% (Mycelex-7). 

Vulvovaginal candidiasis Vaginal (Tablets) 1 tablet (100 mg) at bedtime for 7 days 2 tablets (200 mg) at bedtime for 3 days or 500-mg tablet one time. Vaginal (Cream) 1 applicatorful at bedtime for 7-14 days. 

Topical Itching, burning, stinging, erythema, urticaria Vaginal Mild burning (tablets/cream) irritation, cystitis (cream)... 

Atrophic vaginitis Vaginal Tablet (Vagifem) Initially, 1 tablet/day for 2 weeks. Maintenance 1 tablet twice a week. 

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