Vaginal cream

I = injection T = tablet C = cream Tr = transdermal, continuous delivery, P = parenteral VC = vaginal cream VS = vaginal suppositories Ca = capsule. 

It is not a first-line agent owing to lower efficacy compared with oral metronidazole in non-pregnant populations.38 Avoid clindamycin vaginal cream due to associations with premature labor and neonatal infection.38... 

Clindamycin vaginal cream is the preferred therapy for bacterial vaginosis during lactation because metronidazole is listed as a drug of concern by the American Academy of Pediatrics (AAP)14 (Tables 44—4 and 44—5). Counsel patients that clindamycin cream weakens latex condoms and diaphragms, potentially rendering them ineffective. 

Topical Estrogens Vaginal creams Conjugated equine estrogens 0.5-2g/day... 

CEE vaginal cream (V2-2 g daily PV consider 3 weeks on, 1 week off may be able to decrease frequency of use over time)... 

Ferris DG, Litaker MS, Woodward L, Mathis D, Hendrich J Treatment ofbacterial vaginosis A comparison of oral metronidazole, metronidazole vaginal gel and clindamycin vaginal cream. J Fam Pract 1995 41 443-449. 

Mild vaginal dryness can sometimes be relieved by nonestrogenic vaginal creams, but significant vaginal dryness often requires local or systemic estrogen therapy. 

Vaginal creams, suppositories Microbial Limit Test, TAMC, TCYMC only and AET As above 0, 6, 12, 24, 36 months... 

Conjugated estrogens vaginal cream exposure has been reported to weaken latex condoms. Consider its potential to weaken and contribute to the failure of condoms, diaphragms, or cervical caps made of latex or rubber. 

Vaginal cream contains mineral oil and vaginal suppositories contain an oleaginous base which may weaken rubber or latex products such as condoms, avoid use within 72 hr following treatment with vaginal cream or suppositories... 

Combination Pack Vaginal tablet 100 mg and vaginal cream 1% (Mycelex-7). 

Vaginal Cream 1% (Gyne-Lotrimin, Mycelex-7), 2% (Gyne-Lotrimin 3, Mycelex-3, Trivagizole 3). 

Vulvovaginal candidiasis Vaginal (Tablets) 1 tablet (100 mg) at bedtime for 7 days 2 tablets (200 mg) at bedtime for 3 days or 500-mg tablet one time. Vaginal (Cream) 1 applicatorful at bedtime for 7-14 days. 

Cyclopirox olamine 1% solution, skin cream vaginal cream... 

Topical 2% vaginal cream Butenafine (Lotrimin Ultra, Mentax)... 

Topical 0.4%, 0.8% vaginal cream 80 mg vaginal suppositories Tioconazole (Vagistat-1, Monistat 1)... 

Figure 1 A generalized diagram of the structure of the cetostearyl alcohol gel found in topical and vaginal creams. The bilayers are formed principally of cetostearyl alcohol. The hydrophilic poly(oxyethylene) chains attached to the 5-carbon sorbitan rings in Polysorbate 60 retard water drainage from the interlamellar space and keep the lamellae from collapsing into a dense crystalline structure.

Figure 2 shows the influence of the different phase transitions on the rheological characteristics of a vaginal cream formulation containing cetostearyl alcohol and Poly-sorbate 60 as the emulsifying wax. Incomplete transition of two observable polymorphs... 

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