Antifungal agents synthetic

Uses Preparation of sodium and butyl benzoates, benzoyl chloride, phenol, caprolactum, and esters for perfume and flavor industry plasticizers manufacture of alkyl resins preservative for food, fats, and fatty oils seasoning tobacco dentifrices standard in analytical chemistry antifungal agent synthetic resins and coatings pharmaceutical and cosmetic preparations plasticizer manufacturing (to modify resins such as polyvinyl chloride, polyvinyl acetate, phenol-formaldehyde). 

Potassium permanganate Important reagent in analytical and synthetic organic chemistry used in bleaching applications, disinfectants, antibacterials and antifungal agents used in water purification. 

Pharmacology Fluconazole, a synthetic broad spectrum bis-triazole antifungal agent, is a highly selective inhibitor of fungal cytochrome P450 and sterol C-14 alpha-demethylation. 

Pharmacology Itraconazole is a synthetic triazole antifungal agent. In vitro, itraconazole inhibits the cytochrome P450-dependent synthesis of ergosterol, which is a vital component of fungal cell membranes. 

Ketoconazole, 1% shampoo, apply every 3-4 days Nizoral A-D Synthetic azole antifungal agent with activity versus Pityrosporum ovale, a fungus that may cause seborrhea and dandruff. Massage over entire scalp for 3 minutes. Rinse thoroughly and repeat application. 

Synthetic, broad-spectrum antifungal agent with activity against Candida albicans and other Candida spectes... 

Class Synthetic, broad-spectrum bis-triazole antifungal agent with activity against Cryptococcus neoformans md Candida species ... 

Class Synthetic broad-spectrum antifungal agent with clinical activity against Blastomyces derrnatitidis. Candida specks, Coccidioides immitis, Histoplasma capsulatum, Paracoccidioides brasiliensis. Phialophora species, Trichophyton species, Epidermophyton specks, and Microsporum species... 

G Petranyi, NS Ryder, A Stutz. Allylamine derivatives new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 224 1239-1241,1984. 

The primary search for a lead compound for further medicinal chemistry was, however, still the same. With little in the way of mechanistic information on die synthetic process, discovery of antifungal agents affecting cell wall synthesis has been an empirical process. Although pharmaceuti-... 

Itraconazole [it ra KON a zole] is a recent addition to the azole family of antifungal agents. Like fluconazole it is a synthetic triazole, and it also lacks the endocrinologic side effects of ketoconazole. Its mode of action is the same as that of the other azoles. Itraconazole is now the drug of choice for the treatment of blastomycosis. Unlike ketoconazole, it is effective in AIDS-associated histoplasmosis. However, current studies show that it may also be effective in the treatment of aspergillosis, candidemia, coccidioidomycosis, and cryptococcosis. Thus it has a broad antifungal spectrum. 

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