Anti-tumor

Considerable attention is also being given to the anti-tumor activity of titanium compounds. 

Hagan et al. utilized the Graebe-Ullmann process to synthesize polycyclic acridines 14 which exhibit anti-tumor activity. ... 

Combining anti-VEGF treatment with chemotherapy or radiation therapy results in a greater anti-tumor effect than either of these therapies alone. 

Waldmann H, Thutewohl M (2000) Ras-Farnesyltransferase-Inhibitors as Promising Anti-Tumor Drugs. 211 117-130 Wang G-X, see Chow H-F (2001) 217 1-50 Weil T, see Wiesler U-M (2001) 212 1-40... 

Thomson A], Reslova S, Williams RJP (1972) The Chemistry of Complexes Related to cis-Pt(NH3)2Cl2. An Anti-Tumor Drug. II 1-46 Thomson AJ, see Le Brun NE (1997) 88 103-138... 

Enhancement of anti-tumor activity of 1-p-D-arabino-furanosylcytosine by encapsulation, Int. J. Cancer. 20, 581-587. 

Upadhyay KK, Bhatt AN, Mishra AK, Dwarakanath BS, Jain S, Schatz C, Le Meins JE, Earooque A, Chandraiah G, Jain AK, Misra A, Lecommandoux S (2010) The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(y-benzyl L-glutamate)-b-hyaluronan polymersomes. Biomaterials 31(10) 2882... 

Sarkomycin, an anti-tumor substance produced by streptomyces, H. Umezawa, T. Takeuchi, K. Nitta, T. Yamamoto, and S. Yamaoka, J. Anti-biot A6(1953) 101. 

CCR4-expresssing regulatory T cells is also stimulated via glioma cell secretion of CCL2. This may be an important mechanism whereby gliomas suppress anti-tumor immune responses and evade immune detection (Jordan et al. 2008). 

Tocotrienols are another group of phytochemicals of rice bran which have a chemopreventive effect and have been demonstrated to inhibit breast cancer (Nesaremam et al., 1998). The polysaccharides of rice bran contain a-glucan, the anti-tumor effect of which has been demonstrated by its inhibition of gastrointestinal carcinogenesis (Akeshita et al., 1992). Rice bran agglutinin has been shown to induce apoptosis of cancer cells by the mechanism of cell cycle dysregulation (Miyoshi et al., 2001). 

Epidemiological studies and intervention trials with food and beverages rich in flavonoids are not conclusive although flavonoids were recognized to display numerous antioxidant, anti-inflammatory, anti-tumoral, and anti-microbial activities. The antioxidant capacity of flavonoids has been largely reported in numerous in vitro and ex vivo systems. Numerous reviews "" have been published on the antioxidant properties of flavonoids. Degenerative diseases are largely associated with oxidative mechanisms that may be counteracted by flavonoids. 

Much toxicological data are available on this red pigment acute oral toxicity in mice, 90-day subchronic toxicological study, acute dermal irritation and corrosion, acute eye irritation and corrosion, anti-tumor effectiveness, micronucleus test in mice, AMES test Salmonella typhimurium reverse mutation assay), estimation of antibiotic activity, and results of estimation of five mycotoxins. A new patent on Arpink Red was filed in 2001 with claims of anti-cancer effects of the anthraquinone derivatives and apphcations in the food and pharmaceutical fields. 

Rowley, D.A. and Halliwell, B. (1983). DNA damage by superoxide-generating systems in relation to the mechanism of action of the anti-tumor antibiotic adriamycin. Biochim. Biophys. Acta 761, 86-93. 

While the critical role of intrastrand 1,2-crosslinks in the mechanism of action of the anti-tumor drug cis- [PtCl2(NH3)2] is well established, much less is known about the few frans-analogs that exhibit similar efficacy. A series of 1,3-adducts has been characterized with 3-mers generally involving purine N7 coordination (32-34), and either monofunctional or interstrand adducts are formed with duplex DNA (35). However, one of the most active compounds, frans-[PtCl2 ( )-HN = C(OMe)Me 2], (2), has been shown to form a 1,2-adduct with 2-mer ribonucleotide sequence r(AG) (36). Though the formation of the... 

In E. Coli bacterial lysates, the proteome (i.e., the full array of proteins produced) was analyzed by isoelectric focusing and mass spectrometry.97 A comparison of capillary electrophoretic separation and slab gel separation of a recombinant monoclonal antibody demonstrated that the precision, robustness, speed, and ease-of-use of CE were superior.98 Seventy-five proteins from the yeast ribosome were analyzed and identified by capillary electrophoresis coupled with MS/MS tandem mass spectrometry.99 Heavy-chain C-terminal variants of the anti-tumor necrosis factor antibody DE7 have been separated on capillary isoelectric focusing.100 Isoforms differing by about 0.1 pi units represented antibodies with 0,1 or 2 C-terminal lysines. 

Williams RO, Feldmann M, Maini RN. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci U S A 1992 89(20) 9784—9788. 

Effects of Sesquiterpene Lactones on Seed Germination. Sesquiterpene lactones are common constituents of the Asteraceae but are also found in other angiosperm families and in certain liverworts (31,32). These highly bitter substances exhibit a wide spectrum of biological activities (J 3) which include cytotoxicity, anti-tumor, anti-microbial, insecticidal (34) and molluscicidal (35) properties. Furthermore, they are known causes for livestock poisoning and contact dermatitis in humans (33). Structure-activity relationship studies on sesquiterpene lactones have demonstrated that biological activity frequently depend on the presence of the cr... 

P17. van der Poll, T., Levi, M Van Deventer, S. J., Ten Cate, H., Haagmans, B. L., Biemond, B. J., Buller, H. R Hack, C. E., and Ten Cate, J. W., Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees. Blood 83,446-451 (1994). 

Huang RL, Chen CC, Huang YL, et al. Anti-tumor effects of D-dicentrine from the root of Lindera megaphylla. Planta Med 1998 64 212-215. 

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