Diseases degenerative

Atherosclerosis is a degenerative disease which is characterized by cholesterol-containing thickening of arterial walls. Saturated fatty acids, high levels of cholesterol, elevated blood pressure, and elevated serum lipoprotein are well-knowm risk... 

As cited before (Section VIII.B.l.c), some chiral 1,2,5-thiadiazolidin-3-one 5,5-dioxides were introduced in new pseudonucleosides as aglicone 250 (96T(52)993). Some l,2,5-thiadiazolidin-3-one 5,5-dioxides were prepared for treatment of degenerative disease (95USP15565, 95USP15504,... 

Vitamin C status is supposed to play a role in immune function and to influence the progression of some chronic degenerative diseases like atherosclerosis, cancer, cataracts, and osteoporosis. The role of vitamin C in immune function, especially during common cold and upper respiratory tract infection, is the subject of lively debate. The exact mechanisms of action have not yet been fully elucidated, but the results of several trials point to a reduced duration and intensity of infections in subjects consuming high amounts of vitamin C (200-1000 mg/d). However, the incidence of common cold was not influenced significantly (24). 

In nearly every pharmacy, supermarket, and health food store, you can find bottles of antioxidants and antioxidant-rich natural products, such as fish oils, Gingko biloba leaves, and wheat grass. These dietary supplements are intended to help the body control its population of radicals and, as a result, slow aging and degenerative diseases such as heart failure and cancer. 

The only one of these conditions which causes progressive and degenerative disease of muscle is myotonic dystrophy. Inheritance is autosomal dominant, but expression is very variable. The condition also illustrates the phenomenon of... 

In the pharmaceutical industry, GA is used in pharmaceutical preparations and as a carrier of drugs since it is considered a physiologically harmless substance. Additionally, recent studies have highlighted GA antioxidant properties (Trommer Neubert, 2005 Ali Al Moundhri, 2006 Hinson et al., 2004), its role in the metabolism of lipids (Tiss et al., 2001, Evans et al., 1992), its positive results when being used in treatments for several degenerative diseases such as kidney failure (Matsumoto et al., 2006 Bliss et al., 1996 Ali et al., 2008), cardiovascular (Glover et al., 2009) and gastrointestinal (Wapnir et al., 2008 Rehman et al, 2003). 

McGeer PL, McGeer EG (2004) Inflammation and the degenerative diseases of aging. Ann N Y Acad Sci 1035 104-116... 

Dietary consumption of polyphenols is associated with a lower risk of degenerative diseases. In particular, protection of serum lipids from oxidation, which is a major step in the development of arteriosclerosis, has been demonstrated. More recently, new avenues have been explored in the capacity of polyphenols to interact with the expression of the human genetic potential. The understanding of the interaction between this heterogeneous class of compounds and cellular responses, due either to their ability to interplay in the cellular antioxidant network or directly to affect gene expression, has increased. 

ROE F J c, LEE P N, CONYBEARE G, et al, (1995) The Biosure Study influence of composition of diet and food consumption on longevity, degenerative diseases and neoplasia in Wistar rats studied for up to 30 months post weaning. Food Chemicals Toxicol. 33 Suppl 1 IS-IOOS. 

Epidemiological studies and intervention trials with food and beverages rich in flavonoids are not conclusive although flavonoids were recognized to display numerous antioxidant, anti-inflammatory, anti-tumoral, and anti-microbial activities. The antioxidant capacity of flavonoids has been largely reported in numerous in vitro and ex vivo systems. Numerous reviews "" have been published on the antioxidant properties of flavonoids. Degenerative diseases are largely associated with oxidative mechanisms that may be counteracted by flavonoids. 

Curcumin possesses strong antioxidant capacities, which may explain its effects against degenerative diseases in which oxidative stress plays a major role. As previously described for flavonoids, it is unlikely that curcumin acts as a direct antioxidant outside the digestive tract since its concentration in peripheral blood and organs is very low (near or below 1 pM, even after acute or long-term supplementation). Indeed, it has been shown that the intestinal epithelium limits its entry into the body, as reflected by absorption studies in various models (portal blood perfusion, everted bags). ... 

In atherosclerosis and other heart diseases, the role of carotenoids as antioxidants is probable, but for these types of diseases and also for other degenerative diseases such as cancers, non-antioxidant activities constitute other possible prevention mechanisms. These activities are, for example, stimulation of gap junction communications between cells, and the induction of detoxifying enzymes. The... 

Vitamin A (retinol) and retinoic acid are carotenoid oxidation compounds that are very important for human health. The main functions of retinoids relate to vision and cellular differentiation. With the exception of retinoids, it was only about 10 years ago that other carotenoid oxidation products were first thought to possibly exert biological effects in humans and were implicated in the prevention - or promotion of degenerative diseases. A review on this subject was recently published. ... 

Ames, B.N. (1983). Dietary carcinogens and anticarcinogens oxygen radicals and degenerative diseases. Science 221, 1256-1264. 

Wallace DC (1992) Mitochondrial genetics a paradigm for aging and degenerative diseases. Science 256 628-632. 

Just as TCM, all of the other complementary medicines work mainly in those areas where modern medicine can not produce remarkable or immediate efficacy, such as immunological disease, degenerative diseases, cancer, and mental disorders. Few people will seek alternative resolutions for diseases in which effective treatment is already available, even in the places where complementary medicine is very popular. 

The failure of proteins to fold into their functional forms can occasionally lead to "misfolding" or "conformational" diseases.140 Many of these diseases are associated with the formation of amyloid protein, an insoluble material that is deposited as fibrils or plaques in different tissues and organs of the body. They include amyloid Ap protein as the major constituent of the plaques in Alzheimer patients, PrPc associated with neuro-degenerative diseases, a-synuclein (AS) associated with Parkinson s diseases, transthyretin (TTR) as a homotetrameric protein that is involved in the transport of thyroid hormones and retinol in human serum. In particular, the Ap protein is a peptide of 39-43 amino acids that is the... 

Therefore, in recent years, consumers have been demanding foods that are beneficial to their health, not only for their nutritional value but also for the prevention of chronic and degenerative diseases. This is due to the fact that many chronic diseases are directly related to nutrition and could be prevented with an appropriate diet rich in fruits and vegetables. 

D Harman. In Free Radicals, Aging, and Degenerative Diseases, JE Johnson, Jr., R Walford, D Harman, J Miquel (eds), 1986, pp 3-49. (Liss, New York)... 

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