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Anti-tumor antibiotics

Rowley, D.A. and Halliwell, B. (1983). DNA damage by superoxide-generating systems in relation to the mechanism of action of the anti-tumor antibiotic adriamycin. Biochim. Biophys. Acta 761, 86-93. [Pg.213]

Masjedizadeh and coworkers have recently described similar microwave-promoted hydrogen-deuterium exchange reactions in a series of heterocydes using mixtures of deuterium oxide and deuteriomethanol (Scheme 6.173 b) [328], The rapid exchange method was applied to the deuteration of the anti-tumor antibiotic bleomycin A under catalyst-free conditions [328],... [Pg.219]

The intramolecular G-H insertion of aryldiazoacetates is a very powerful strategy for synthesizing heterocyclic rings such as dihydrobenzofurans and dihydrobenzopyrans. The first effective asymmetric copper-catalyzed C-H activation reaction was reported by the group of Sulikowski in the synthesis of the anti-tumor antibiotic FR-66979 93 (Scheme 7)123 219 The G-H insertion of the aryldiazoacetate 90 formed four diastereomeric products 91a, 91b, 92a,... [Pg.193]

The densely functionalized cyclopentyl core 10 of the potent anti-tumor antibiotic viridenomycin 11 was prepared by treatment of enone 8 with catalyst C (Scheme 2). This reaction proved to be very slow, requiring 3.5 days to give still only incomplete conversion leading to cyclization product 9 in 69% (86%, based on recovered 8). [Pg.208]

Kedarcidin is a chromoprotein anti-tumor antibiotic, produced by an actinomycete strain. It is an acidic complex with an apparent molecular weight of 12,400 Da, and it consists of an apoprotein and a cytotoxic highly unstable nonprotein chromophore 12 that possesses a conformationally defined ansamacrocyclic bridge. Retrosynthetically,... [Pg.208]

Fig. (10). Alkylation of adenine with anti-tumor antibiotic CC-1065, which possesses a Spyrocyclopropane in conjugation with a carbonyl group through four carbon atoms. Fig. (10). Alkylation of adenine with anti-tumor antibiotic CC-1065, which possesses a Spyrocyclopropane in conjugation with a carbonyl group through four carbon atoms.
The Pictet-Spengler reaction has also been developed on solid-support materials. This advancement provided the opportunity for the synthesis of an array of structurally diverse analogues of saframycin A, an important anti-tumor antibiotic. [Pg.518]

Anti-tumor antibiotics Doxorubicin, Actinomycin-D Side effect treatment related leukemia... [Pg.18]


See other pages where Anti-tumor antibiotics is mentioned: [Pg.112]    [Pg.826]    [Pg.252]    [Pg.350]    [Pg.8]    [Pg.458]    [Pg.478]    [Pg.541]    [Pg.778]    [Pg.715]    [Pg.174]    [Pg.760]    [Pg.44]    [Pg.400]    [Pg.42]    [Pg.826]    [Pg.353]   


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