Subject Anti-tumor activity

Taxol has had a most unusual clinical development history. As with many natural products that have been discovered to provide therapeutic benefit to humans, it was the extract of a plant that provided the first hint of the oncological potential of this product. Natural product chemists typically subject purified plant extracts to screening for therapeuhc achvity. In 1963, an extract of the bark of the Pacific yew tree (Taxus brevifolia (Figure 7.2) showed anti-tumor activity. This early work was done by Monroe Wall and Monsukh Wani of the Research Triangle Institute (RTI) under the auspices of the National Cancer Institute (NCI) [3]. 

The so-called cis-platin has been the subject of numerous studies related to its antitumoral activity (anti-cancerous). For comparison, sila-cis-platin under the form of its salts (chloride A, sulfate B and oxalate C) has been prepared and its anti-tumor activity tested against L-1210 leukemia in male mice.499,500... 

Amaravadi RK, Schilder RJ, Dy GK, et al (2011) Phase 1 study of the smac mimetic TL32711 in adult subjects with advanced solid tumors lymphoma to evaluate safety, pharmacokinetics, pharmacodynamics and anti-tumor activity. In 2011 annual AACR conference, Orlando, FL... 

In the first chapter of this volume the wide variety of bioactive macrocyclic natural products is explored, including examples of those with clinically validated anti-infective and anti-tumor activity. Many of these natural products have been the subject of drug discoveiy efforts that have leveraged semi-synthesis, biosynthesis and total synthesis in order to investigate or optimize their pharmacological effects and viability as drugs. The medicinal... 

Six quassinoids isolated from Eurycoma tongifolia Jack, were subjected to in vitro tests on anti-tumor promoting. The most active compound for inhibition of tumor promoter-induced Epstein-Barr virus activation was 14,15 p-dihydroklaineanone (136, ICso= 5pM) [109]. This inhibitory potential was much higher than quercetin (IC50" 23 pM) and p-carotene (ICjo- 30 pM), two common antitumor promoting natural agents [110],... 

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