Anti-tumor activity tests

The so-called cis-platin has been the subject of numerous studies related to its antitumoral activity (anti-cancerous). For comparison, sila-cis-platin under the form of its salts (chloride A, sulfate B and oxalate C) has been prepared and its anti-tumor activity tested against L-1210 leukemia in male mice.499,500... 

Compounds 2, 5, 6, 7, 9,11,18,19, 20, 22, 24, 25, 27, 28 had been tested for anti-tumor activity tests on Lung cancer 7721, Stomach Cancer MKN-28, Mouse leukemia P388, and no activity was found. 

CS144 Sato, A. Studies on anti-tumor activ- CS155 ity of crude drugs. 1. The effects of aqueous extracts of some crude drugs in short-term screening test. Yaku-gaku Zasshi 1989 109(6) 407-423. 

Anti-thyroid activity. Boiled rice taken orally by adults at a dose of 350 g/person was inactive on iodine uptake by the thyroid Anti-tumor activity. Bran, administered intraperitoneally to mice at a dose of 100 mg/kg, was active on Sarcoma 180 (solid). The biological activity has been patented . Fermented grains, in the ration of rats, were active. Miso, a paste made from the seeds of Oryza sativa and G lycine max (soybean), was fed ad libitum. The incidence of cancers in the miso treated rats was 20% less than controls vs 7,12-dimethylbenz-[a]anthracene -induced carcinogenesis ". Water extract of dried seed hull, administered intraperitoneally to mice, was active on Sarcoma 180 (ASC). A glycoprotein fraction has been tested. The biological activity reported has been patented . Anti-ulcer activity. A cerebroside fraction of rice bran, administered intraperitoneally to mice at a dose of 100 mg/kg, was inac-... 

Since the period that commenced about the end of World War II, several thousand plants growing in Australia and New Guinea have been screened for alkaloids, and many hundreds of new bases, as well as large numbers of known ones, have been isolated. The greater part of this work was accomplished by the CSIRO in collaboration with the American pharmaceutical firm SKF, which carried out a wide range of pharmacological testing, and the US Cancer Chemotherapy National Service Center, which examined materials for anti-tumor activity. A... 

Some of the compounds from Evodia lepta had been tested for insecticide activity, anti-fungus activity, anti-tumor activity and anti-HIV activity. The results will be discussed as follows. 

A pure compound for which IC5o 5 M is likely to enter the phase of/o v/Vo tests. One then refers to anti-tumor activity. 

The iV-oxide of indicine (100) does disply anti-tumor activity with less toxic effects than related pyrrolizidine alkaloids it has recently been tested on humans 176). Some semi-synthetic quaternary pyrrolizidine derivatives block neuromuscular transmissions, and their synthesis and biological activities have recently been reviewed 19, 261). 

MTX and its derivatives were tested for anti-tumor activity in mice using the protocol recommended by the Drug Evaluation Branch, National Cancer Institute (7). Animals were inoculated with 10 ... 

Much toxicological data are available on this red pigment acute oral toxicity in mice, 90-day subchronic toxicological study, acute dermal irritation and corrosion, acute eye irritation and corrosion, anti-tumor effectiveness, micronucleus test in mice, AMES test Salmonella typhimurium reverse mutation assay), estimation of antibiotic activity, and results of estimation of five mycotoxins. A new patent on Arpink Red was filed in 2001 with claims of anti-cancer effects of the anthraquinone derivatives and apphcations in the food and pharmaceutical fields. 

The thiazoloimidazopyridine derivatives 451 were tested for their effect on human immunodeficiency virus (HIV)-induced cytopathogenicity in a human T4-lymphocyte cell line and showed a reproducible anti-HIV activity that caused a 50% or greater reduction of viral cytophatic effect <1994FA345>. Finally, imidazo[2,1 -/dthiazolone 489 was found to have an antitumor activity and proved to be effective against brain tumor cell lines <2002JHC1133>. 

GlaxoSmithKline has filed patent applications covering 5-(benzimidazol-l-yl)thiophenes 111 and 112 and 2-(benzimidazol-l-yl)thioazoles 113 as inhibitors of PLK-1 [274,275]. Many potent compounds were claimed for 5-(benzimidazol-l-yl)thiophene series, including analog 111 with submicromolar inhibition against PLK-1 and anti-proliferative activity in five out of the six tumor cell lines tested. According to the data disclosed in the filing, a variety of substituents were accommodated on the 5- and 6-positions of the ben-... 

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