Lipids anti-tumor activity

Antitoxic effect. Sesame oil, adiministered to male Wistar rats, ameliorated hepatic and renal damage in a dose-dependent manner and increased survival in lipopolysaccha-ride-treated rats. It decreased lipid peroxide concentration in serum but not in liver and kidney. Serum nitrite production was unaffected by sesame oil ingestion, and the activity of xanthine oxidase was reduced in the lipopolysaccharide-challenged rats k Anti-tumor activity. Water extract of the dried seed, administered intragastrically to mice at a dose of 50 mg/animal daily for 5 days, was active on CA-Ehrlich-ascites, 18% increase in life-span. Intraperitoneal administration was active on Dalton s lyphoma and CA-Ehrlich-ascites, 19 and 39% increase in life-span, respectively ". Seed oil, administered to rats intraperito-neally with 1,2,5,6-dibenzanthracene or re-tene, was active on sarcoma ". 

Ras is strictly localized to the inner side of the plasma membrane. A lipid anchor covalently attached to the C-terminus of Ras penetrates into the lipid bilayer. This membrane anchorage is essential for the biological activity of Ras. Hence, the inhibition of anchor attachment has become an attractive pharmacological target [ 13]. See Waldmann H, Thutewohl M,Ras-Farnesyltransferase-inhibitors as promising anti-tumor drugs, this volume. 

The modification of plasma lipid profiles by rice bran oil has been extensively studied and is the major health benefit highlighted in this section. Other health benefits associated with components of rice bran oil include suppression of B16 melanoma cell proliferation by y- and P-tocotrienols (He et al., 1997 Qureshi et al, 1997, 2000 Lane et al, 1999) and inhibition of tumor-promoting activity by oryzanols (Yasukawa et al, 1998 Akihisa et al, 2000). Cicero and Gaddi (2001) have reviewed other health benefits, including modulation of pituitary secretion and anti-ulcerogenic activity. 

The additional use of interferon-gamma (IFN-gamma and IL-lbeta) in tumors made of a colon adenocarcinoma chemically induced in a BD IX rat (DHD/K12-PROb) enhanced the anti-tumor effects during lipid A treatment by increasing iNOS activity and NO concentration in tumor tissues (Onier et al. 1999). 

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