Anti-tumor-promoting activities

Murakami, A., S. Jiwanjiinda, K. Koshi-mizu, and H. Ohigashi. Screening form vitro anti-tumor promoting activities of edible plants from Thailand. Cancer Lett 1995 95(1/2) 137-146. 

Screening of edible plants against pos- DC230 sible anti-tumor promoting activity. 

Screening of edible plants against possible anti-tumor promoting activity. Cancer Lett 1988 39(3) 247-257. Chen, C. P., C. C. Lin, and T. Namba. Development of Natural Crude Drug Resources from Taiwan. VI. In vitro studies of the inhibitory effect on 12 microorganism. Shoyakugaku Zasshi... 

Vimala, S., A. W. Norhahnom, and M. Yadav. Anti-tumor promoter activity in Malaysian ginger rhizobia used in traditional medicine. Brit J Cancer 1999 80(1/2) 110-116. 

Konoshima, T., M. Takasaki, M. Kozuka, H. Tokuda, H. Nishino, E. Matsuda, and M. Nagai. 1997. Anti-tumor promoting activities of isoflavonoids from Wistaria brachybotrys. Biol. Pharm. Bull. 20 865-868. 

Nishino, H. Okuyama, T. Takata, M. Shibata, S. Tokuda, H. Takayasu, J. Hasegawa, T. Nishino, A. Ueyama, H. Iwashima, A. Studies on the anti-tumor-promoting activity of naturally occurring substances IV. Pd-H [(+)anomalin, (- -)praeruptorin B], a seselin-type coumarin, inhibits the promotion of skin tumor formation by 12-O-tetradecanoyl-phorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated mice. Carcinogenesis (London), 1990, 11 1557-1561. 

In recent years, the anti-tumor-promoting activities of several natural products [102] have been investigated for inhibition of 12-0-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation [103]. Compounds isolated from T. wilfordii var. regelii were assayed by Takaishi and coworkers [27] on... 

Anti-tumor-promoting activity on two-stage carcinogenesis test on mouse skin using DMBA and TPA. ... 

Anti-tumor promoting activity on a two-stage carcinogenesis test on mouse skin using DMBA and croton oil. Increase the life span of transplanted DLA and EAO harboring mice and reduces the volume of transplanted solid tumors [101]... 

These anti-tumor-promoting activities are extremely high in our experiments, and these results strongly suggested that amorphispironone (33) and tephrosin (34) might be valuable as cancer chemopreventive agents in chemical carcinogenesis [21]. 

Because the anti-tumor-promoting activity in vivo would be expected on the basis of these in vitro results, the inhibitory effects of 46 and 47 on the two-stage carcinogenesis of mouse skin tumors were investigated. As shown in Fig. (7), on the positive control, 55, 90 and 100% of mice bore... 

On the basis of the results of the in vitro assays (inhibitory effects on EBV-EA activation and effects on the cell cycle of Raji cells induced by the promoter, TPA), the anti-tumor-promoting activities of 59 and 66 on the two-stage carcinogenesis test would be expected. 

Triterpenoids (including triterpenoid glycosides) are also widely distributed in plants kingdom as well as flavonoids. For searching new anti-tumor-promoters from natural resources, we have also been researching on triterpenoids rich plants which have been used for medicinal purpose in several countries. For a start, from Leguminous plants, many kinds of oleanene type triterpenoid saponins had been isolated and their anti-tumor-promoting activities were examined. 

Glycyrrhetin from licoris have been well known as an oleanane type saponin which having the anti-tumor-promoting activity, and in our... 

These cucurbitane triterpenoids have been well known as bitter principles in Cucurbitaceous plants, but compound 114 had a strong sweet taste. The cytotoxic activities of several cucurbitane triterpenes have already been reported, but the anti-tumor-promoting activities of these triteijienoids have not been reported thus far. Therefore, there is quite a possibility that novel chemopreventive agents will be developed from cucurbitane glycosides. 

Figure 9 Anti-tumor promoting activity of nobiletin in DMBA-initiated ICR mouse skin. Each group was composed of 15-17 female ICR mice, and all were given commercial rodent pellets and fresh tap water ad libitum, freshly exchanged twice a week. The back of each mouse was shaved with a surgical clipper 2 days before initiation.

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