Anti-tumor promoters

Murakami, A., S. Jiwanjiinda, K. Koshi-mizu, and H. Ohigashi. Screening form vitro anti-tumor promoting activities of edible plants from Thailand. Cancer Lett 1995 95(1/2) 137-146. 

Screening of edible plants against pos- DC230 sible anti-tumor promoting activity. 

Yoshida, and S. Mizusaki. Identification of cembratriene-4,6-diol as anti-tumor-promoting agent from cigarette smoke condensate. Carcinogenesis... 

Screening of edible plants against possible anti-tumor promoting activity. Cancer Lett 1988 39(3) 247-257. Chen, C. P., C. C. Lin, and T. Namba. Development of Natural Crude Drug Resources from Taiwan. VI. In vitro studies of the inhibitory effect on 12 microorganism. Shoyakugaku Zasshi... 

Vimala, S., A. W. Norhahnom, and M. Yadav. Anti-tumor promoter activity in Malaysian ginger rhizobia used in traditional medicine. Brit J Cancer 1999 80(1/2) 110-116. 

Murakami, A. et al., Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters, Biosci. Biotechnol. Biochem., 56, 769, 1992. 

Konoshima, T., M. Takasaki, M. Kozuka, H. Tokuda, H. Nishino, E. Matsuda, and M. Nagai. 1997. Anti-tumor promoting activities of isoflavonoids from Wistaria brachybotrys. Biol. Pharm. Bull. 20 865-868. 

El-Sayed, N. H. 1991. A rare kaempferol trisaccharide anti-tumor promoter from Sesbania sesban. Pharmazie 46 679-680. 

On the other hand, morusin (3) itself did not show a tumor promoting activity on mouse skin, x in Figs. (10) and (11). From these results, morusin (3) is an anti-tumor promoter judging from its ability to inhibit the short-term effects induced by tumor promoters. 

As described in Chapter III, morusin (3) has been found to be anti-tumor promoter in a two-stage carcinogenesis experiment with teleocidin. Considering the similarity of the structures between morusin (3) and artonin E (7), artonin E (7) was expected to be an anti-tumor promoter. Furthermore we found a novel photo-oxidative cyclization of artonin E (7) as follow photo-reaction of artonin E (7) in CHCI3 containing 4% ethanol solution with high-pressure mercury lamp produced artobiloxanthone (8) and cycloartobiloxanthone (9), and the treatment of artonin E (7) with radical reagent (2,2-diphenyl-1-picrylhydrazyl DPPH) resulted in the same products, Fig. (15), [84]. 

Figure 2. General structure of retinoic acid (all trans-retinoic acid). Of the many derivatives tested (e.g., retinol, retinyl acetate), none has the "anti-tumor promoter efficacy, in vivo, as retinoic acid.

ANTI-TUMOR- INITIATORS ANTI TUMOR-PROMOTERS ... 

Nishino, H. Okuyama, T. Takata, M. Shibata, S. Tokuda, H. Takayasu, J. Hasegawa, T. Nishino, A. Ueyama, H. Iwashima, A. Studies on the anti-tumor-promoting activity of naturally occurring substances IV. Pd-H [(+)anomalin, (- -)praeruptorin B], a seselin-type coumarin, inhibits the promotion of skin tumor formation by 12-O-tetradecanoyl-phorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated mice. Carcinogenesis (London), 1990, 11 1557-1561. 

Gonzalez AG, Tincusi BM, Bazzocchi IL, Tokuda H, Nishino H, Konoshima Y, Jimenez lA, Ravelo AG. Anti-tumor promoting effects of sesquiterpenes from Maytenus cuzcoina (Celastraceae). Bioorg. Med. Chem. 2000 8 1773-1778. 

Lophira alata Banks ex Gaertn (leaves) Bongosin (290) lophirone L (217) lophirone M (216). Cameroonian medicinal plant. Anti-tumor promoters. Tih et ah, 1990[284] Murakami et al., 1992[281] Tih et al.,2006. 

As already shown, tubeimoside 1 (5) from Bobolstemma paniculatum exhibited a strong anti-tumor activity, but had intriguingly a potent antitumor-promoting effect in two-stage mouse skin tumor formation induced by DMBA+TPA [38]. Its natural analog, tubeimoside III showed also a potent anti-tumor-promoting effect in the same model after topical administration but not after oral administration [39]. 

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