Anti-cancer effect

Anti-cancer effect (Nesaretnam et. al., 1998) Human mammary and large intestinal cancer inhibition (Nesaretnam et al., 1998). 

Anti-cancer effect protection from most common cancers such as colon, breast, and prostate cancer (Awad and Fink, 2000). 

Much toxicological data are available on this red pigment acute oral toxicity in mice, 90-day subchronic toxicological study, acute dermal irritation and corrosion, acute eye irritation and corrosion, anti-tumor effectiveness, micronucleus test in mice, AMES test Salmonella typhimurium reverse mutation assay), estimation of antibiotic activity, and results of estimation of five mycotoxins. A new patent on Arpink Red was filed in 2001 with claims of anti-cancer effects of the anthraquinone derivatives and apphcations in the food and pharmaceutical fields. 

Scheme 16.1 Anti-cancer effect of A3AR agonists - De-regulation of the NF-kB and the Wnt signaling pathways, resulting in cell cycle arrest and apopotosis of cancer cells...

Fishman P, Jacobson KA, Ochaion A, Cohen S, Bar-Yehuda S (2007) The anti-cancer effect of A3 adenosine receptor agonists a novel targeted therapy. Immun Endoc Metab Agents Med Chem 7 298-303... 

There have been several epidemiological and several case reports inversely relating ascorbic acid intake from food to human cancer mortality. These studies are interesting, but may be confounded with the fact that the same ascorbic acid containing foods, namely fruits and vegetables, also contain large amounts of vitamin A and fiber. Both vitamin A and fiber have been inversely related to human cancer mortality and have been shown to inhibit several types of chemically-induced carcinogenesis in animals. Therefore, the possible anti cancer effect of ascorbic acid may be due to other factors. 

Hegedus C et al (2009) Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2 implications for altered anti-cancer effects and pharmacological properties. BrJ Pharmacol 158 1153-1164... 

Williams, E.A., Coxhead, J.M., Mathers, J.C. 2003. Anti-cancer effects of butyrate use of micro-array technology to investigate mechanisms. Proc. Nutr. Soc. 62, 107-115. 

Recently, Mendoza et al. [227] focused on the molecular pathways governing apoptosis and summarized recent peptide-based approaches that target mdm-2, p53, NF-kB, ErbB2, MAPK, as well as Smac/DIABLO, lAP BIR domains, and Bcl-2 interaction domains, particularly BH3. A special attention was given to the anti-cancer effect of proteasome inhibitors (PI). 

Camptothecin is one of the bioactive components isolated from the fruits and leaves of Camptotheca acuminata Decne in China. Also camptothecin has anti-cancer effects.2 7-Ethyl- 10-hydroxycamptothecin (EHC), a camptothecin derivative, has stronger anti-cancer effects and weaker side-effects than camptothecin,3 however, its interaction mechanism with protein is poorly understood. 

Kenner, D. 2006. Avemar—a Functional Food with Proven Anti-Cancer Effects. Townsend Letter for Doctors and Patients, nos. 277/278 (Angnst/September) 96-100. 

Skalnikova, H., Halada, P., Dzubak, P., Hajduch, M., Kovarova, H. (2005). Protein fingerprints of anti-cancer effects of cyclin-dependent kinase inhibition Identification of candidate biomarkers using 2-D liquid phase separation coupled to mass spectrometry. Technology in Cancer Research Cf Treatment, 4, 447—454. 

McCaleb, Rob. "Anti-Cancer Effects of Herbs." HerbalGram, no. 30, winter 1994, page 10. 

Utsuki T, Brem H, Pitha J, Loftsson T, Kristmundsdottir T, Tyler BT, Olivi A. Potentiation of anti-cancer effects of micro-encapsulated carboplatin by hydroxypropyl a-cyclodextrin. J Contr Rel 1996 40 251-260. 

Bleomycin is much used in the clinic because of its rapid attack on solid forms of cancer. It is one of the very few anti-cancer drugs that does not attack the bone-marrow. Its characteristic toxicity (fibrosis of the lung, and some effect on skin) is not shared with the few other drugs that are effective against solid tumours, such as doxorubicin and cisplatin. Hence, bleomycin is given (parenterally) in conjunction with one of these, so that the anti-cancer effect is additive whereas the toxicity to healthy cells in minimized (Carter and Blum, 1976 Carter /a/., 1976). 

Thymine-propenal 4.31) is profoundly cytotoxic. It is not yet known whether the anti-cancer effect of bleomycin is largely due to the base-propenals to which it degrades the DNA of tumours. 

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