Tumors adenocarcinomas

J,l/mouse, twice a week for 25 weeks, to female ICR mice produced forestomach tumors (squamous cell carcinoma and papilloma), lung tumors (adenocarcinoma and adenoma), and tumors of the hematopoietic system (thymic lymphosarcoma and lymphatic leukemia), with dose-related response by 18 months. It was concluded that the target organ of benzotrichloride carcinogenesis in mice is the local tissue that is primarily exposed and the lung and hematopoietic tissue when administered systemically. 

Type I tumor Adenocarcinoma of the distal esophagus, which usually arises from an area with specialized intestinal metaplasia of the esophagus (i.e., Barrett s esophagus) and which may infiltrate the esophagogastric junction from above. 

Mekenyan OG, Bonchev D, Rouvray DH, Petichev D, Bangov I. Modeling the interaction of small molecules with biomacromolecules. IV. The in-vivo interaction of substituted purines with murine tumor adenocarcinoma CA 755. Eur J Med Chem 1991 26 305-312. 

A 2-h incubation with another PGE2 analogue, nocloprost (9P-chloro-DMPG) protects normal human fibroblasts but has no effect on the survival of colon adenocarcinoma cells exposed to 10 Gy (1000 rad) (218). Nocloprost protects against radiation-induced DSBs in normal cells but not in tumor cells. Moreover, incubation using nocloprost for 2 h after irradiation enhances the rate of DSB rejoining in fibroblasts but not in adenocarcinoma cells. These data possibly reflect a different distribution of PG receptors on the plasma membrane of the two cell types. 

In an animal study of rats exposed by inhalation to ethylene oxide at 10, 33, or 100 ppm for approximately two years (245), and in a separate chronic rat study in which rats were exposed to 50 or 100 ppm of ethylene oxide (240), increased incidences of mononuclear cell leukemia, peritoneal mesothelioma, and various brain tumors have been reported. In an NTP (246) two-year inhalation study of mice at 50 and 100 ppm, alveolar/bronchiolar carcinomas and adenomas, papillary cystadenomas of the harderian gland, and malignant lymphomas, uterine adenocarcinomas, and mammary gland tumors were increased in one or both exposure groups. 

Herbst, A.L., Ulfelder, H., and Poskanze, D.C. (1971). Adenocarcinoma of vagina—association of maternal stilbestrol therapy with tumor appearance in young Women. New England Journal of Medicine 284, 878-881. 

In male Sprague-Dawley rats, there was a dose-related increase in testicular Leydig cell tumors and a slight increase in tubular renal adenocarcinoma at the 600-ppm exposure level after exposure for 104 weeks (Maltoni et al. 1986, 1988). EPA and other groups regard such increases as indicative of a hazard potential unless there are reasons to rule this out. However, other authorities believe testicular tumors are common in rats that are not exposed to toxic substances. 

The incidence of pulmonary adenocarcinomas was significantly increased over controls in female ICR mice exposed to 150 or 450 ppm reagent grade trichloroethylene for 104 weeks, 5 days/week, 7 hours/day (Fukuda et al. 1983). There was no significant increase in other tumors in the mice or in similarly exposed female Sprague-Dawley rats. The amount of epichlorohydrin (approximately 0.019%) was extremely low in this... 

Malkinson, A. M. Primary lung tumors in mice an experimentally manipulable model of human adenocarcinoma. Cancer Res. 1992, 52, 2670s-2676s. 

Over 90% of colon cancers are adenocarcinomas and are assigned a grade of I to III based on how similar they are to normal colon cells. Grade I tumors most closely resemble normal cellular structure, whereas, grade III tumors frequently have lost the characteristics of mature normal cells. Grade III tumors are associated with a worse prognosis than grade I tumors.8... 

The normal prostate is composed of acinar secretory cells arranged in a radial shape and surrounded by a foundation of supporting tissue. The size, shape, or presence of acini are almost always altered in the gland that has been invaded by prostatic carcinoma. Adenocarcinoma, the major pathologic cell type, accounts for more than 95% of prostate cancer cases.15 Much rarer tumor types include small cell neuroendocrine cancers, sarcomas, and transitional cell carcinomas. 

Epithelial ovarian tumors are composed of cells that cover the surface of the ovary, such as serous, mucinous, endometrioid, clear cell, and poorly differentiated adenocarcinomas. 

Adenocarcinoma Malignant tumor originating in glandular tissue. 

CCR2 expression was also examined in liver tumor formation induced by intraportal injection of a murine colon adenocarcinoma cell line (58). Tumor growth occurred at similar rates in wild-type and CCR2 /" mice, but the number... 

The lead-induced nephropathy observed in humans and rodents shows a comparable early pathology (Goyer 1993). However, in rodents, proximal tubular cell injury induced by lead can progress to adenocarcinomas of the kidney (see Section 2.2.3.8). The observation of lead-induced kidney tumors in rats may not be relevant to humans. Conclusive evidence for lead-induced renal cancers (or any other type of cancer) in humans is lacking, even in populations in which chronic lead nephropathy is evident. 

Blechschmidt K, Kremmer E, Hollweck R, et al. The E-cadherin repressor snail plays a role in tumor progression of endometrioid adenocarcinomas. Diagn. Mol. Pathol. 2007 16 222-228. 

Shir A, Ogris M, Wagner E, Levitzki A (2006) EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice. PLoS Med 3 e6... 

Exposure Group Adenomas Adenocarcinomas + Squamous Cell Carcinomas Squamous Cysts Only All Tumors... 

Adenocarcinomas account for more than 90% of tumors of the large intestine. 

The less polar methyl ester 2 as prodrug showed better results in vivo and inhibits both farnesylation of the Ras protein and growth of Ras-transformed cells, whilst proliferation of Raf- or Mos-transformed cells was not influenced. Growth of human pancreatic adenocarcinoma cells with mutated K-Ras, c-Myc and p53 genes was inhibited by application of 2. If the compound is administered over a period of 5 days to mice with implanted Ras-dependent tumors, tumor growth can be reduced by up to 66% compared to untreated mice, whereas application of the antitumor antibiotic doxorubicin only resulted in 33% reduction under the same conditions. It is particularly noteworthy that treatment with the /1-turn mimetic - in contrast to treatment with doxorubicin - was without any visible side effects, such as weight loss. 

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