Murine tumor

Mirabelli, C.K., Johnson, R.K., Sung, C.M., Faucetter, L., Muirhead, K. and Crooke, S.T. (1985) Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models. Cancer Research, 45, 32-39. 

C25. Cross, A. S., Sadoff, J. C., Kelly, N., Bemton, E., and Gemski, P., Pretreatment with recombinant murine tumor necrosis factor-alpha/cachectin and murine interleukin 1 -alpha protects mice from lethal bacterial infection. J. Exp. Med. 169,2021-2027 (1989). 

In spite of the heavy atom, compound (32) is sufficiently fluorescent for this to be used as an analytical tool to examine localization and pharmacokinetics. In EMT-6 murine tumors, (32) localizes initially on lysosomes, with selectivity for tumor over surrounding normal tissue, and with evidence for apoptotic cell kill.137 Fluorescence studies using a hamster cheek pouch model show a maximum emission in 2-3 h, with selectivity for the tumor (x 1.5 over normal tissue) after 24 h the photosensitizer is no longer detectable.138 Lutetium texaphyrin (32) has been compared... 

Heckelsmiller, K. et al., Combined dendritic cell- and CpG oligonucleotide-based immune therapy cures large murine tumors that resist chemotherapy, Eur. J Immunol, 32, 3235, 2002. 

K. V., and Sloane, B. F., Cathepsin B to cysteine proteinase inhibitor balance in metastatic cell subpopulations isolated from murine tumors. Cancer Res. 50, 6278-6284 (1990). 

A compound of a very similar structure is phenazinomycin (67), which has been isolated from mycelial extracts of Streptomyces sp. WK-2057 by Omura et al. [69]. This compound possesses in vivo antitumor activity against experimental murine tumor cells and cytotoxic activity against adriamycin-resistant... 

Comparative Antitumor Activity of Selected 4-Deacetyl vinblastine Amides against Several Murine Tumor Models... 

Milas L, Furuta Y, Hunter N, et al. Dependence of indomethacin-induced potentiation of murine tumor radioresponse on tumor host immunocompetence. Cancer Res 1990 50 4473 1477. 

Furuta Y, Hunter N, Barkley T Jr, et al. Increase in radioresponse of murine tumors by treatment with indomethacin. Cancer Res 1988 48 3008-3013. 

P.S. Hees, C.H. Sotak, Assessment of changes In murine tumor oxygenation in response to nicotinamide using F NMR relaxometry of a perfluorocarbon emulsion, Magn. Reson. Med. 29 (1993) 303-310and erratum 329 716 (1993). 

Hibbs, J. B., Jr., Lambert, L. H., and Remington, J. S. (1971). Resistance to murine tumors conferred by chronic infection with intracellular protozoa, Toxoplasma gondii and Bes-noitiajellisoni. J. Infect. Dis. 124, 587-592. 

Nakagawa, M., Yamaguchi, T., Fukawa, H., Ogata, J., Komiyama, S., Akiyama, S., and Kuwano, M. (1985). Potentiation by squalene of the cytotoxicity of anticancer agents against cultured mammalian cells and murine tumor. Jpn. ]. Cancer Res. 76, 315-320. 

Sharma, A., Mayhew, E., and Straubinger, R. M. (1993). Antitumor effect of taxol-containing liposomes in a taxol-resistant murine tumor modSancer Res., 53, 5877-5881. 

A recent study has utilized an in vivo murine tumor model expressing human HER-2 for evaluating potential HER-2 vaccines consisting of either full-length or variable subunits of HER-2 delivered in either protein or plasmid DNA form (discussed later) (Foy et al., 2001). The mechanism of protection elicited by plasmid DNA vaccination appears to be exclusively CD4-dependent and not CD8- or antibody-dependent, whereas the protection observed with intracellular domain protein vaccination requires both CD4 and CD8 T cells. However, the exact mechanism(s) responsible for immunity to DNA has not been elucidated. 

Chen, C.H., Ji, H., Suh, K.W., Choti, M.A., Pardoll, D.M. and Wu, T.C. (1999) Gene gun-mediated DNA vaccination induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the liver and lungs. Gene Ther., 6, 1972-1981. 

Rakhmilevich, A.L., Turner, J., Ford, M.J., McCabe, D., Sun, W.H., Sondel, P.M., Grota, K. and Yang, N.-S. (1996) Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors. Proc. Natl. Acad. Sci. USA, 93, 6291-6296. 

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