Lung tumor

The National Toxicology Program (NTP) reported on tests on mice and rats that there was an increase in the spontaneous incidence of benign tumors in male and female rats and an increase in malignant Hver and lung tumors in B6C3E1 mice. NTP concluded that these data demonstrated clear evidence of carcinogenicity in mice and female rats and some evidence in male rats (35). 

NPIP induces esophageal and nasal cavity tumors in the rat, forestomach, liver and lung tumors in the mouse, and tracheal tumors in the Syrian golden hamster (43, 44, 45). Its potent carcinogenicity is indicated by the fact that a single dose of only 22 mg/kg was sufficient to induce tumors in 20% of Syrian golden hamsters (45). The environmental occurrence of NPIP appears to be less frequent than that of NPYR, but it has been detected in food (J, 44). 

Malkinson, A. M. Koski, K. M. Evans, W. A. Festing, M. F. Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcho-lanthrene. Cancer Res. 1997, 57, 2832-2834. 

Bauer, A. K. Dwyer-Nield, L. D. Hankin, J. A. Murphy, R. C. Malkinson, A. M. The lung tumor promoter, butylated hydroxytoluene (BHT), causes chronic inflammation in promotion-sensitive BALB/cByJ mice but not in promotion-resistant CXB4 mice. 

Malkinson, A. M. Primary lung tumors in mice an experimentally manipulable model of human adenocarcinoma. Cancer Res. 1992, 52, 2670s-2676s. 

Currently, one of the most promising agents for the prevention of lung cancer is selenium, which appeared to prevent the development of lung tumors in patients with skin cancer.15 This has not yet been shown in patients without preexisting skin cancer, although studies are underway. 

Poirier LA, Theiss JC, Arnold LJ, et al. 1984. Inhibition by magnesium and calcium acetates of lead subacetate and nickel acetate-induced lung tumors in strain A mice. Cancer Res 44 1520-1522. 

Shvedova et al. [59] demonstrated that inhalation of SWNTs resulted in mutations of the k-ras gene locus in the lung of mice. Among the mutated genes implicated in pulmonary tumorigenesis, the k-ras oncogene is relevant in lung tumors of mice exposed to chemicals. 

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