Tumors progression

PI3K Elevated PI3K has been observed in a variety of human cancers and is implicated in transformation and tumor progression... 

Luan J, Shattuck-Brandt R, Haghnegahdar H, et al. Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression. J Leukoc Biol 1997 62(5) 588-597. 

Porter DA, Krop IE, Nasser S, et al. A SAGE (serial analysis of gene expression) view of breast tumor progression. Cancer Res 2001 61 5697-5702. 

Generally, changes in the tumor marker concentration reflect changes in tumor burden. It has been reported that an increase in the tumor marker concentration is associated with tumor recurrences. An increase of 25 percent or more can be due to tumor progression. Similarly, a decrease could be due to tumor regression or response to therapy (18, 28, 32). 

Blechschmidt K, Kremmer E, Hollweck R, et al. The E-cadherin repressor snail plays a role in tumor progression of endometrioid adenocarcinomas. Diagn. Mol. Pathol. 2007 16 222-228. 

Yang CS, Yang GY, Landau JM, Kim S and Liao J. 1998. Tea and tea polyphenols inhibit cell hyperproliferation, lung tumorigenesis, and tumor progression. Exp Lung Res 24(4) 629-639. 

Block of endometrial tumor progression Athymic mice ICI 164384 (Gottardis et al. 1990)... 

When studied in a model of human endometrial carcinoma, such as EnCa 101 tumors in athymic mice, ICI 164384 not only showed no stimulatory activity on tumor progression but also blocked the tamoxifen-stimulated growth of the tumor (Gottardis et al. 1990). 

Fusenig, N. E., and P. Boukamp. 1998. Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes. Mol Carcinog 23(3) 144—58. 

I. M. Berquin, B. F. Sloane, Cysteine Proteases and Tumor Progression , Perspect. Drug Discov. Design 1995, 2, 371-388. 

Tumor-educated macrophages. (From Pollard, J.W., Tumor-educated macrophages promote tumor progression and metastasis, Nat. Rev. Cancer, 4, 71-74, 2004. Copyright year 2004, Macmillan Magazines Ltd and the author. Reproduced with permission from Macmillan.)... 

VHL patients have VEGF Endpoints Time to tumor progression Response rate (only four responses)... 

In addition to trying to individualize patient therapy there is still a great need for additional endpoints to evaluate the efficiency of new agents. For example, the endpoint of time to tumor progression has been proposed. A type of endpoint such as that would allow us to conduct randomized placebo controlled trials (with crossover) (see Figure 23.4). 

Gallo, O., Masini, E., Morbidelh, L., Eranchi, A., Eini-Storchi, 1., Vergaii, W. A., and Ziche, M., 1998, Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer, J. Natl. Cancerinst. 90 587-596. 

Currently, more than 400 human somatic cell gene therapy protocols are being tested. Most of these involve the use of genetically modified cells to treat noninherited diseases. For example, normal copies of the p53 tumor suppressor gene are inserted into lung tumors to halt tumor progression, and genetically modified cells have been used to create new coronary vessels in patients with coronary heart disease. Success has also been achieved in the treatment of hereditary disease (most notably, the recent successful treatment of X-linked severe combined immune deficiency see Clinical Correlate). 

EPITHELIAL PLASTICITY OF HEPATOCYTES DURING LIVER TUMOR PROGRESSION... 

Mikula M, Proell V, Fischer AN, Mikulits W (2006). Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-beta dependent fashion. J Cell Physiol 209 560-567. 

Beta-1-6 branched oligosaccharides as a marker of tumor progression in human breast and colon neoplasia. 

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