Lymphatic leukemia

Acute lymphatic leukemia, acute or chronic myelogenous leukemia... 

L Slater, P Sweet, M Stupecky, S Gupta. (1986). Cyclosporin A reverses vincristine and daunomycin resistance in acute lymphatic leukemia in vitro. J Clin Invest 77 1405-1408. 

The answer is c. (Hardman, pp 1238-1239.) Remission maintenance can be carried out by combination therapy, which includes cyclophosphamide. Cyclophosphamide causes hemorrhagic cystitis. Doxorubicin and carmustine are useful in the treatment of acute lymphatic leukemia, but neither is known to cause hemorrhagic cystitis. 

In the Pre-Carpathian biogeochemical province with prevalent Eutric Podsolu-visols, enriched in lead and barium and depleted in chromium and vanadium, the predominant diseases are mieloleukemia, chronic lymphatic leukemia, hemorrhagic vasculitis, hypoanemia with a relatively low number of sharp leukemia, lung and stomach cancer. 

In leucocytes of individuals suffering from myelocytic and lymphatic leukemia a significant decrease of G-6-PDH and 6-PGDH has been described (B3, B4, G4), the activity of the latter being noticeably more reduced than that of the former. 

J,l/mouse, twice a week for 25 weeks, to female ICR mice produced forestomach tumors (squamous cell carcinoma and papilloma), lung tumors (adenocarcinoma and adenoma), and tumors of the hematopoietic system (thymic lymphosarcoma and lymphatic leukemia), with dose-related response by 18 months. It was concluded that the target organ of benzotrichloride carcinogenesis in mice is the local tissue that is primarily exposed and the lung and hematopoietic tissue when administered systemically. 

In humans, cases of hepatomas have appeared years after acute exposure to carbon tetrachloride, however, none of the cases could establish a causal link between the exposure and development of neoplasms." Epidemiological studies have also given inconclusive results. A cancer mortality study of a population of rubber workers reported a significantly elevated odds ratio relating carbon tetrachloride with lymphatic leukemia, and lymphosarcoma and reticulum cell carcinoma." A recent retrospective cohort mortality study of aircraft maintenance workers found an increased risk of... 

Serum Iq s in Other Lymphoid Neoplasia— Hodgkin s Disease, Reticulum Cell Sarcoma, Lymphosarcoma, and Chronic Lymphatic Leukemia... 

Methotrexate is used to treat severe lymphatic leukemia, choriocarcinoma, non-Hodgkin s lymphoma, bone carcinoma, as well as head, neck, breast, and lung tumors. Synonyms of this drug are farmitrexate, ledertrexate, ematexate, maxtrex, folex, mexate, and others. 

Chlorambucil is well adsorbed when administered orally. It is used for chronic lymphatic leukemia and for multiple myelomas. Synonyms of this drug are leukeran, amboclorin, and others. 

High rates of rash in patients on allopurinol, with mononucleosis, lymphatic leukemia... 

Malignant diseases Corticoids are used in combination with other therapy in the treatment of Hodgkin s disease, acute lymphatic leukemia and other lymphomas. 

The status of the extensive clinical trials of L-asparaginase against a number of forms of cancer, especially acute lymphatic leukemia, has been thoroughly treated in several recent reviews (106-109) and will not be dealt with here. 

A. O Maaa, M. Daly, and P. H, Hattinan. Increased antilhnanhin 111 concentration in children with acute lymphatic leukemia recaving 1-asparaginase therapy. Mad. 

ICI 42, 464-induced myeloid and lymphatic leukemias Alderly Park rats % ILS = 400 % b)... 

Chronic myelogenous Acute lymphatic leukemia Breast carcinoma... 

Hairy-cell leukemia is a rare form of lymphatic leukemia. Proliferation of the malignant cells is very efficiently inhibited by interferon-a. This is one of the few cases so far in which a biological therapy has actually lived up to its promise. 

Leukemias are classified according to the lines of blood cell precursors they arise from. Lymphatic leukemia and myeloid leukemia are most common. 

For leukemic forms no interrelation was found between metabolite abnormality and behavior of the peripheral blood picture. In 4 cases with chronic myeloid leukemia, a tremendous increase in the leucocyte counts (300,000 in one subject) did not correspond to any abnormal excretion. Kynurenine excretion is, however, frequently increased in patients with chronic lymphatic leukemia, which is related to the malignant lymphogranuloma through the same genesis of the lymphoreticular matrix. 

Pauwels, M., Pauwels, S., Capron, XR, Sevestre, H., Desablens, B. Intra-hepatic portal hypertension during chronic lymphatic leukemia. Gastroenterol. Clin. Biol. 2000 24 221—224... 

Patients with chronic lymphatic leukemia or with concurrent infection with Epstein-Barr virus or HIV have an increased frequency of ampicillin- and amoxicillin-associated rashes (280). 

Myeloschisis occurred in a 6-week-old human embryo whose 39-year-old mother had taken busulfan before and during the early stages of gestation for chronic lymphatic leukemia (36). Histology showed reduced mesenchymal elements together with somite disorganization in the affected area of the embryo. 

The antileukemic effect of ciclosporin has been harnessed in the treatment of cytopenias associated with chronic lymphatic leukemia. In 31 patients the most common adverse effect was a raised serum creatinine concentration of grade 2 or worse in six patients (19%) three patients developed opportunistic infections (4). 

Fludarabine can cause or exacerbate autoimmune thrombocytopenia in chronic lymphocytic leukemia. Two patients with chronic lymphatic leukemia who developed thrombocytopenia while taking fludarabine were treated... 

A second malignancy in a patient taking methotrexate for chronic lymphatic leukemia has been described (123). 

The authors thought that T cell deficiency induced by methotrexate, chronic lymphatic leukemia, and rheumatoid arthritis may have contributed to the development of the B cell lymphoma. 

Trade names Ribomustin (Mundipharma) Treanda (Cephalon) Indications Chronic lymphatic leukemia Category Alkylating agent Half-life 40 minutes... 

Lymphoid neoplasia 10% Reticulosarcoma 12% Mycosis fungoides 9% Hodgkin s disease 34% Lymphosarcoma 40% Giant follicular lymphoma 60% Chronic lymphatic leukemia Spindle cell thymoma... 

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