Lymphomas malignant

Malignant lymphomas Malignant lymphomas, which may regress following withdrawal of methotrexate, may occur in patients receiving low-dose methotrexate and, thus, may not require cytotoxic treatment. Discontinue methotrexate first and, if the lymphoma does not regress, institute appropriate treatment. 

Noncarcinomatous lesions Plasma cell tumors, L H cells of Hodgkin lymphoma, few cells of non-Hodgkin lymphoma, anaplastic large cell lymphoma, malignant peripheral nerve sheath tumors, synovial sarcoma, leiomyosarcoma... 

Despite dramatic advances in the treatment of several human malignancies including Hodgkin s lymphomas and leukemias, dmg resistance remains a pressing issue in cancer chemotherapy. Acquired or induced dmg resistance afflicts practically all classes of cancer agents. It usually is manifested clinically... 

L-asparaginase therapy with an extra-corporeal device in patients with malignant lymphoma has resulted in repeated remissions of metastases (242). This technique utilizes L-asparaginase covalentiy bound to the surface of a battery of plates contained in a portable chamber which has been inserted between an artery and vein. 

In an animal study of rats exposed by inhalation to ethylene oxide at 10, 33, or 100 ppm for approximately two years (245), and in a separate chronic rat study in which rats were exposed to 50 or 100 ppm of ethylene oxide (240), increased incidences of mononuclear cell leukemia, peritoneal mesothelioma, and various brain tumors have been reported. In an NTP (246) two-year inhalation study of mice at 50 and 100 ppm, alveolar/bronchiolar carcinomas and adenomas, papillary cystadenomas of the harderian gland, and malignant lymphomas, uterine adenocarcinomas, and mammary gland tumors were increased in one or both exposure groups. 

Patients in the more aggressive categories are less likely to exhibit involvement of the skin and have a less favorable prognosis [10]. Those patients may have a definable hematological disorder such as a myelodysplastic syndrome, myeloproliferative disorder, acute leukemia, or a malignant lymphoma. In aggressive mastocytosis and mast cell leukemia, the clinical course is determined by the rapidity of the increase in mast cell numbers. 

Epstein-Barr virus (EBV) Enveloped, icosahedral particles 150nm in diameter Infections occur by salivary exchange. In young children they are commonly asymptomatic but the virus persists in a latent form in lymphocytes. Infection delayed until adolescence often results in glandularfever. In tropical Africa, a severe EBV infection early in life predisposes the child to malignant facial tumours (Burkitt s lymphoma)... 

Hardell L, Eriksson M, Lenner P, et al. 1981. Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids A case-control study. Br J Cancer 43 169-176. 

B and T cells can undergo neoplastic transformation that is governed by specific mutations in their chromosomes that result in populations of malignant lymphoma cells. 

The diagnosis of malignant lymphomas is established by tumor biopsy sample, analysis of the biopsy tissue, and determination of the extent of the disease in the patient. 

The malignant lymphomas are hematologic cancers that consist of a cluster of diseases of the lymphoid tissue. The primary malignant cells for lymphomas are lymphocytes of B-cell, T-cell, and NK-cell origin. These cells originate from a small population of... 

---