Lung tumors primary

Malkinson, A. M. Primary lung tumors in mice an experimentally manipulable model of human adenocarcinoma. Cancer Res. 1992, 52, 2670s-2676s. 

Figure 3. Primary epithelial lung tumor rate in rats as a function of Rn-d exposure.

Dermal exposure of mice to 1,2-dibromoethane has resulted in cutaneous neoplasms and increased incidences of primary lung tumors. 

Lantry, L.E., Zhang, Z., Crist, K.A., Wang, Y., Kelloff G.J., Lubet, R.A. and You, M. (1999) 5-Aza-2 -deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino) -1- (3 -pyridyl) -1 -butanone-induced primary mouse lung tumor model. Carcinogenesis, 20, 343-346. 

Murphy, J. B., and Sturm, E. (1925). Primary lung tumors in mice following the cutaneous application of coal tar. J Exp Med 42, 693-700. 

Rare cases of lung carcinoma can metastasize to the head and neck, particularly to the low cervical lymph nodes. These tumors usually carry the same immunophenotype as the primary lung tumor. Typical stains that are used to aid in this differential diagnosis will include cytokeratin 7, cytokeratin 20, and thyroid transcription factor-1 (TTF-1). 

Jerome-Marson V, Mazieres J, Groussard O, et al. Expression of TTE-1 and cytokeratins in primary and secondary epithelial lung tumors Correlation with histological type and grade. Histopathology. 2004 45 125-134. 

Carcinoid tumor, metastatic, lung 80 primary Sclerosing hemangioma of 100 lung—cuboidal cells and polygonal cells... 

E. Brambilla, Mdm2 overexpression and pl4ARF inactivation are two mutually exclusive events in primary human lung tumors, Oncogene 2002, 21, 2750-2761. 

Garbow JR, Zbang Z, You M. Detection of primary lung tumors in rodents by magnetic resonance imaging. Cancer Res 2004 64 2740-2742. 

Malkinson AM. Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung. Lung Cancer 2001 32 265 -279. 

Vogl TJ, Fieguth HG, Eichler K, Straub R, Lehnert T, Zangos S et al (2004c) Laser-induced thermotherapy of lung metastases and primary lung tumors. Radiologe 44(7) 693-699... 

The size of both primary and metastatic lung tumors often exceeds 3 cm in diameter at the time of diagnosis. The RF electrodes of the three leading companies currently in use are designed for a maximum ablation diameter of 5 cm. Therefore, the tumor to be ablated should not exceed 3 cm in maximum diameter, as a 1-cm safety ablation margin surrounding the tumor should ideally be achieved. 

Immunohistochemical studies relate polysialic acid-NCAM expression to tumor malignancy in neuroblastoma, alveolar rhabdomyosarcoma [189], neuroendocrine lung tumors [190], Wilm s tumor [191], aggressive colon cancers [192], and pancreatic cancer [193]. In studies on the role of polysialic acid in tumor cell behavior, endosialidase has been used as a tool to remove polysialic acid from the surface of cells and tumors. In a metastasis model using human rhabdomyosarcoma TE671 cells, endoNA injected intraperitoneally reduces the expression of polysialic acid and the number of lung and liver metastases formed from intraperi-toneal primary tumors [194]. For comparison, the effect was not seen with intramuscular primary tumors that cannot be reached by the intraperitoneally injected endosialidase. 

Campbell JA (1937) The effects of road dust freed from tar products upon the incidence of primary lung-tumors of mice. Br J Exp Pathol 18 215-223. 

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