Pulmonary adenocarcinoma

The incidence of pulmonary adenocarcinomas was significantly increased over controls in female ICR mice exposed to 150 or 450 ppm reagent grade trichloroethylene for 104 weeks, 5 days/week, 7 hours/day (Fukuda et al. 1983). There was no significant increase in other tumors in the mice or in similarly exposed female Sprague-Dawley rats. The amount of epichlorohydrin (approximately 0.019%) was extremely low in this... 

Loy, T. S. and Calaluce, R. D. (1994) Utility of cytokeratin immunostaining in separating pulmonary adenocarcinomas from colonic carcinomas. Am. J. Clin. 

Hydrazine or hydrazine salts are carcinogenic in mice after oral administration (pulmonary adenocarcinoma hepatocarcinoma) or intraperitoneal injection (pulmonary carcinoma) and in rats after oral administration (pulmonary adenocarcinoma). Hydrazine induced a significantly greater incidence of nasal tumors, primarily benign, in rats and in hamsters after 1 year of intermittent inhalation exposure at levels up to 5.0ppm. ... 

Masi, T. et al. 2005. Nitrosamine 4-(methylnitrosamino) -1 - (3-pyridyl) -1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta-2-adrenergic receptor single-nucleotide polymorphisms. Genes Chromosomes Cancer, 44 (2), 212-217. 

Ryan PJ, Oates JL, Crocker J, et al. 1997. Distinction between pleural mesothelioma and pulmonary adenocarcinoma using MOC31 in an asbestos sprayer. Resp Med 91 57-60. 

Watanabe N, Tanada S, Oriuchi N et al (2000) Tumor uptake of radioiodinated antihuman pulmonary surfactant-associated protein monoclonal antibody PE10 in nude mice bearing hitman pulmonary adenocarcinoma in combination with an unlabeled preload. Nucl Med Biol 27(8) 723-731... 

FIGURE 8.13 Thyroid transcription factor 1 (TTF-1) antibody identifies 60% to 70% of pulmonary adenocarcinomas (A, B) and 95% of pulmonary small cell carcinomas (C, D). 

Recently, the absolute specihcity of GCDFP-15 has also been challenged. Striebel and colleagues reported GCDFP-15 immunoreactivity in 5.2% (11/211) of pulmonary adenocarcinomas. These tumors were characteristically of mixed acinar and papillary types with abundant extracellular mucin production. However, 81% percent of these tumors co-expressed TTF-1, which would be helpful in their distinction from breast carcinomas. 

Villin is a calcium-dependent actin-binding cytoskeletal protein that is found in the brush border of the intestine and in the proximal renal tubular epithelium. A brush border is characteristic of colorectal carcinomas and is recognized at the ultrastructural level by the presence of microvilli with a dense core of microfilaments, core rootlets, and surface glycocalyx. Up to 33% of pulmonary adenocarcinomas may demonstrate microvillus rootlets... 

Dabbs DJ, Landreneau RJ, Liu Y, et al. Detection of estrogen receptor by immunohistochemistry in pulmonary adenocarcinoma. Ann Thorac Surg. 2002 73 403-405 discussion 406. 

Nambu Y, lannettoni MD, Orringer MB, Beer DG. Unique expression patterns and alterations in the intestinal protein villin in primary and metastatic pulmonary adenocarcinomas. Mol Carcinog. 1998 23 234-242. 

Tan J, Sidhu G, Greco MA, et al. Villin, cytokeratin 7, and cy-tokeratin 20 expression in pulmonary adenocarcinoma with ul-trastructural evidence of microvilli with rootlets. Hum Pathol. 1998 29 390-396. 

Ordonez NG. Thyroid transcription factor I is a marker of lung and thyroid carcinomas. Adv Anat Pathol. 2000 7 123-127. Kaufmann O, Dietel M. Thyroid transcription factor-I is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. Histopathology. 2000 36 8-16. 

Wick MR, Toy T, Mills SE, et al. Malignant epithelioid pleural mesothelioma versus peripheral pulmonary adenocarcinoma A histochemical, ultrastructural, and immunohistologic study of 103 cases. Hum Pathol. 1990 21 759-766. 

Keratins are a family of polypeptides that have been separated according to molecular weight and isoelectric point (acidic or basic). Twenty molecular species exist and have been catalogued by Moll and colleagues i CK7 is expressed in many pulmonary epithelial cells, although is found in a variety of other epithelial cells and in a variety of nonpulmonary carcinomas.CK7 is the most commonly found molecular species of keratin in primary pulmonary adenocarcinoma. CK5 is found... 

Vimentin is a 58-kD intermediate filament found predominantly in mesenchymal cells. However, vimentin is expressed in most spindle cell carcinomas and is reported by some to be expressed in a relatively high percentage of pulmonary adenocarcinomas. Thyroid transcription factor-1 (TTF-1), a 38- to 40-kD transcription factor member of the NKx2 family of home-odomain transcription factors, is expressed in thyroid and pulmonary epithelial cells. 49 TTF-1 binds to and activates the promoters for Clara cell secretory protein and surfactant proteins A, B, and As reported... 

TTF-1. Also, 11% of lung adenocarcinomas detected by Nap-A were missed by TTF-1 staining. The authors concluded that Napsin A was a valuable marker for detecting lung adenocarcinomas versus other adenocarcinomas such as those from the breast, colon, biliary tract, pancreas, urinary bladder, and ovary. It was less useful in distinguishing primary pulmonary adenocarcinomas from thyroid carcinomas and renal carcinomas. 

TABLE 12.17 Comparison of Immunohistochemical Features of Primary Mucinous Pulmonary Adenocarcinomas versus Metastatic Colonic Adenocarcinomas ... 

---