Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Site-specificity

In theory, it should be possible to design a carrier prodrug that would only release the drug in the vicinity of its site of action. Furthermore, once released, the drug should remain mainly in the target area and only slowly migrate to other areas. In addition the carrier should be metabolized to nontoxic metabolites. Unfortunately, these requirements have only been achieved in a few cases. [Pg.198]

Unfortunately this approach has not been very successful for producing site specific antitumour drugs. However, site specific prodrugs have been developed to deliver drugs to a number of sites. [Pg.199]


The site specificity of reaction can also be a state-dependent site specificity, that is, molecules incident in different quantum states react more readily at different sites. This has recently been demonstrated by Kroes and co-workers for the Fl2/Cu(100) system [66]. Additionally, we can find reactivity dominated by certain sites, while inelastic collisions leading to changes in the rotational or vibrational states of the scattering molecules occur primarily at other sites. This spatial separation of the active site according to the change of state occurring (dissociation, vibrational excitation etc) is a very surface specific phenomenon. [Pg.911]

Sellers H 1991 On modeling chemisorption processes with metal cluster systems. II. Model atomic potentials and site specificity of N atom chemisorption on Pd(111) Chem. Phys. Lett. 178 351-7... [Pg.2236]

Many phenomena ask for local, site-specific properties of a molecule such as the partial charge on a specific atom in a molecule or the hydrogen bond donor ability of a certain OH group. It would be highly desirable to have methods as simple as an additivity model to estimate such site-specific molecular properties. [Pg.327]

In many chemical applications, however, it would be more interesting to know how polarizability can stabilize a charge introduced into a molecule. Thus, rather than the global molecular property, mean molecular polarizability, a local, site-specific value for polarizability is needed. [Pg.333]

The unmodified and complementary oligonucleotides were also synthesized, in order to detect thermodynamic and spectroscopic differences between the double helices. Circular dichroism spectra revealed that the covalently bound anthracene does not stack in the centre of the DNA double helix. Mutagenic activity by intercalative binding of the anthracene residue is thus unlikely. Only in vitro and in vivo replication experiments with site-specifically modified... [Pg.342]

It IS convenient to distinguish between enantiomeis by prefixing the sign of iota tion to the name of the substance Foi example we lefei to one of the enantiomeis of 2 butanol as (+) 2 butanol and the othei as (—) 2 butanol Optically pure (+) 2 butanol has a specific rotation ol of +13 5° optically pure (—) 2 butanol has an exactly oppo site specific rotation ol of —13 5°... [Pg.289]

Capital and operating costs for soda ash production are extremely site specific (29,10). Key factors iaclude iafrastmcture development, freight to consumers, local energy and labor costs, and by-product saleabiUty. 1990 Hst price of bulk natural soda ash was 108/t, F.O.B. Wyoming. [Pg.526]

Analytical and Test Methods. Many of the procedures for technical analyses of magnesium hydroxide are readily available from the principal producers. These procedures should be carefully reviewed. Site-specific variations in procedure steps and mechanics, especially for chemical activity, can bias results and inadvertantiy disqualify an otherwise acceptable product. [Pg.349]

Y. Shimizu and co-workers, "Life Span Study Report 11, Part 1, Comparison of Risk Coefficients for Site-Specific Cancer MortaUty," Technical Report RERF-TR-12-87, Radiation Effect Research Foundation, Hiroshima, Japan, 1987. [Pg.247]

HammerheadRtbozyme. A small RNA molecule that catalyzes cleavage of the phosphodiester backbone of RNA is known as the hammerhead ribozyme. This ribozyme occurs namrally in certain vimses where it facihtates a site-specific self-cleavage at the phosphate and generates a 2 3 -cychc phosphate and a 5 -hydroxyl terminus. The reaction requires a divalent metal ion, such as or, as a cofactor. Whereas the... [Pg.256]

Modified oligonucleotides can be used to cross-link DNA sequences via a reactive group tethered to an oligonucleotide. When irradiated with uv light, psoralens (31) reacts with thymine bases, and the reaction yields a cross-link if the thymine residues are adjacent to each other on opposite strands. Psoralen linked to oligonucleotides have been shown to induce site-specific cross-links in vitro (51). [Pg.266]

Federal regulations (72) administered by the EPA estabHsh limitations on the ammonia in aqueous effluents on a site-specific basis. The range of values is 0.05—0.1875 kg of ammonia (as nitrogen) per ton of product on a maximum daHy basis corresponding 30-day average values range from 0.025 to... [Pg.353]

Sustainable Agriculture. The third factor that will influence the future of pesticide sales is the emphasis on sustainable agriculture systems that rely on more natural pest control methods and reduced pesticide usage. These are integrated systems that requke nutrients and crop protection chemicals from on-farm natural sources and cultural methods. Many current sustainable farms are site-specific systems that may depend on the soils in a... [Pg.224]

To date (ca 1996) many potentially usefiil sucrose derivatives have been synthesized. However, the economics and complexities of sucrochemical syntheses and the avadabiLity of cheaper substitutes have limited their acceptance hence, only a few of them are in commercial use. A change in the price and availability of petroleum feedstocks could reverse this trend. Additional impetus may come from regioselective, site-specific modifications of sucrose to produce derivatives to facilitate and improve the economics of sucrochemical syntheses. For example, the microbe yigwbacterium tumifaciens selectively oxidizes sucrose to a three-keto derivative, a precursor of alkylated sucroses for detergent use (50). Similarly, enzymes have been used for selective synthesis of specific sucrose derivatives (21). [Pg.6]


See other pages where Site-specificity is mentioned: [Pg.910]    [Pg.910]    [Pg.277]    [Pg.297]    [Pg.297]    [Pg.226]    [Pg.341]    [Pg.344]    [Pg.822]    [Pg.161]    [Pg.326]    [Pg.87]    [Pg.97]    [Pg.106]    [Pg.265]    [Pg.273]    [Pg.55]    [Pg.45]    [Pg.387]    [Pg.455]    [Pg.314]    [Pg.45]    [Pg.250]    [Pg.250]    [Pg.266]    [Pg.181]    [Pg.7]    [Pg.8]    [Pg.198]    [Pg.206]    [Pg.493]    [Pg.185]    [Pg.218]    [Pg.221]    [Pg.233]   
See also in sourсe #XX -- [ Pg.312 ]

See also in sourсe #XX -- [ Pg.442 ]




SEARCH



Absorption site-specific

Active site specificity

Active sites specific site TOFs

Active-site-specific inhibitors

Active-site-specific inhibitors proteases

Analysis site specificity

Annihilation on specific molecular sites

Benzaldehyde site-specific deuterium

Benzomorphans specific receptor sites

Biologic applications, site-specific stability

Blocking non-specific binding sites on the membrane

Calcium site specificity

Calcium specific sites

Chemical delivery systems site-specific

Chemical delivery systems site-specific enzyme-activated

Compliance site-specific drug delivery

Covalent immobilization site-specific

Deuterium site-specific distribution

Drug delivery site-specific

Drug release site-specific

Drug site-specific

EcoRl site specificity

Enzyme-based delivery systems, site-specific

Evaluation of site specific hazards

Excipients Used in Site-Specific-Release Formulations

Exposure assessments site-specific characterizations

Exposure scenarios, site-specific

Functionalization, site-specific

Gene delivery systems site-specific

Glutamate dehydrogenase coenzyme site and specificity

Glycosylation site-specific, analysis

Hydrogen-bonding— specific-site solvation

Immobilization of Specific Binding Sites

Inhibition active-site-specific

Intermolecular, Site-specific and Positional Isotope Ratio Analysis

Labeling site-specific

Lesions containing site-specific

Ligand-receptor interactions, specific sites

Mechanical integrity site specific

Monitoring statistics site specificity

Mutagenesis site-specific

Mutagenesis site-specific, lysozyme

Mutations, site specific active sites

Noncovalent immobilization site-specific

Oligosaccharides site-specific processing

Organometallics Targeted to Specific Biological Sites the Development of New Therapies

Other Site Specific Criteria

Photoaffinity labeling site-specific

Polymerase chain reaction site-specific mutagenesis

Polymeric Prosthetic Systems for Site-Specific Drug Administration Physical and Chemical Properties

Probes, site-specific, sources

Prodrugs site specific

Prodrugs site-specific delivery

Prodrugs site-specific drug release

Prodrugs site-specific oral delivery

Protease cleavage site specificity

Proteases active-site-specific

Proteases site-specific modifications

Protein site-specific modification

Proteins site-specific conjugation

Receptor binding site-specific mutation

Recombinase site-specific

Revising Site-Specific Safety Rules

Risk assessment process site-specific

Segregation site-specific

Selection of Specific Binding Site Molecular Recognition

Site Specific Turnover Frequencies

Site specific affinity

Site specific free radical generation

Site specific integration

Site specific natural isotope fractionating

Site specific safety plan

Site specific studies

Site-Specific Health and Safety Plan

Site-Specific Interior Complexations

Site-Specific Internal Functionalization of Nucleic Acids with Transition-Metal Ligands and Other Moieties

Site-Specific Issues

Site-Specific Modification of Proteins

Site-Specific Nephrotoxicity

Site-Specific Polymerization of Methacrylate Monomers

Site-specific

Site-specific DNA cleavage

Site-specific activation

Site-specific assessments

Site-specific batches

Site-specific character

Site-specific chemical

Site-specific chemical modifications

Site-specific conditions modeling

Site-specific conditions modeling consequence screening

Site-specific criteria

Site-specific delivery

Site-specific delivery of drugs

Site-specific deoxyribonuclease

Site-specific drug delivery brain targeting

Site-specific drug delivery cell targeting

Site-specific ecological risk

Site-specific enzyme-activated

Site-specific imaging

Site-specific immobilization

Site-specific influencing factors

Site-specific interactions

Site-specific ligand fragments

Site-specific management

Site-specific markers

Site-specific mechanism

Site-specific modification characteristics

Site-specific modification of enzyme sites

Site-specific modifications

Site-specific monitoring

Site-specific mutagenesis principle

Site-specific mutagenesis restriction—selection

Site-specific mutants

Site-specific mutation

Site-specific natural isotope

Site-specific natural isotope fractionation

Site-specific natural isotope fractionation NMR

Site-specific natural isotope fractionation by nuclear magnetic

Site-specific natural isotope fractionation nuclear magnetic resonance

Site-specific natural isotope resonance

Site-specific pharmacologic

Site-specific polymerization

Site-specific recognition

Site-specific recombinases

Site-specific recombination

Site-specific recombination genome

Site-specific release

Site-specific remedial objective

Site-specific restriction endonucleases

Site-specific screening

Site-specific simulation models

Site-specific stability data, for drug and biologic applications

Site-specific target levels

Site-specific targeting

Site-specific water quality criterion

Site-specifically platinated DNA

Sites specific heat

Sites specific surface

Solvation sphere specific sites

Sorption sites, specific

Specific Amino Acids at the Active-Site Involved in Catalysis and Substrate Binding

Specific binding site

Specific interaction sites of sugar molecules

Specificity canonical site

Specificity site directed mutagenesis

Subtilisin site-specific mutations

Target site, specificity

Target site, specificity labeling

The Law of Mass Action, binding sites and receptors—understanding why specific, potent biological activity is a rare property for any one chemical to possess

Topoisomerases cleavage-site specificity

Towards site-specific approaches

Widely employed site-specific reagents

© 2024 chempedia.info