Site-specific delivery of drugs

Table 1 Reasons for Site-Specific Delivery of Drugs Pharmaceutical...

This time controlled release tablet with a designated lag time followed by a rapid release may provide an alternative to site-specific delivery of drugs with optimal absorption windows or colonic delivery of drugs that are sensitive to low pH or enzyme action for the treatment of localized conditions such as ulcerative colitis, Crohn s disease, and irritable bowel syndrome (IBS). Also, by controlling a predetermined lag time of drug from dosage form, the release behavior can be matched with the body s circadian rhythm pattern in chronotherapy. 

M. K. Bijsterbosch and T. J. C. Van Berkel, Lactosylated high density lipoprotein a potential carrier for the site-specific delivery of drugs to parenchymal liver cells, Mol. Pharmacol. 47 404-411 (1992). 

Drug delivery Site-specific delivery of drugs. Ideally, these NPs could bear a pharmaceutical drug that could be driven to the target organ and be released there. 

Domb A, Langer R, Maniar M (1992) Site specific delivery of drugs using absorbable Polymers. Polym Adv Tech special issue (in press)... 

Since latex dispersion application properties are related to the surface properties of the latex particles, there is a need for surface characterization of the particles at large. Historically, these types of systems have been applied as model colloids (Hearn et al, 1981) and therefore required well-characterized surfaces but as the sophistication of new coatings increase, the latex particle surfaces become more important from an industrial perspective. In addition to these applications the utilization of latex particles in pharmaceutical and biomedical applications has also contributed to the development of new surface characterization methods. The surface engineering, that is, variations in size, surface charge and surface hydrophobicity, of latex particles as colloidal carriers has been demonstrated to provide opportunities for the site-specific delivery of drugs (Ilium Davis, 1982). Surface... 

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