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Chemical delivery systems site-specific

Classical carrier-linked prodrugs Site-specific chemical delivery systems Macromolecular prodrugs Drug-antibody conjugates... [Pg.24]

A special group of carrier-linked prodrugs are the site-specific chemical delivery systems [23], Macromolecular prodrugs are synthetic conjugates of drugs covalently bound (either directly or via a spacer) to proteins, polypeptides, polysaccharides, and other biodegradable polymers [24],... [Pg.24]

N. Bodor, Novel Approaches to the Design of Safer Drugs Soft Drugs and Site-Specific Chemical Delivery Systems , in Advances in Drug Research , Ed. B. Testa, Academic Press, London, Vol. 13, 1984, p. 255-331. [Pg.28]

Novel approaches to the design of safer drugs Soft drugs and site-specific chemical delivery systems, 13, 255... [Pg.278]

N. Bodor and J. J. Kaminski, Prodrugs and site-specific chemical delivery systems, Annu. Rep. Med. Chem. 22 303 (1987). [Pg.190]

The prodrug methenamine, described above in this chapter (Scheme S-17), can be considered a site-specific chemical delivery system for the urinary tract antiseptic agent fotmal-dehyde. The low pH of the urine promotes the hydrolysis... [Pg.156]

Produced by site-specific chemical delivery systems... [Pg.485]

Tissue-selective activation of classical prodrugs Site-specific delivery of ad hoc chemical systems... [Pg.24]

Figure 16.2 Dihydropyridine-pyridinium salt redox system for site-specific and sustained delivery to the brain. The prodrug A is delivered directly to the brain, where it is oxidized and trapped as the prodrug B. The quaternary ammonium salt is slowly cleaved by chemical/enzymatic action with sustained release of the biologically active phenylethylamine C and the facile elimination of the carrier molecule D. Elimination of the drug from the general circulation is by comparison accelerated, either as A or B or as cleavage products... Figure 16.2 Dihydropyridine-pyridinium salt redox system for site-specific and sustained delivery to the brain. The prodrug A is delivered directly to the brain, where it is oxidized and trapped as the prodrug B. The quaternary ammonium salt is slowly cleaved by chemical/enzymatic action with sustained release of the biologically active phenylethylamine C and the facile elimination of the carrier molecule D. Elimination of the drug from the general circulation is by comparison accelerated, either as A or B or as cleavage products...
See other pages where Chemical delivery systems site-specific is mentioned: [Pg.25]    [Pg.433]    [Pg.596]    [Pg.178]    [Pg.179]    [Pg.376]    [Pg.3008]    [Pg.155]    [Pg.156]    [Pg.157]    [Pg.724]    [Pg.172]    [Pg.173]    [Pg.485]    [Pg.536]    [Pg.576]    [Pg.724]    [Pg.602]    [Pg.525]    [Pg.522]    [Pg.257]    [Pg.533]    [Pg.580]    [Pg.226]    [Pg.87]    [Pg.30]    [Pg.98]    [Pg.370]    [Pg.170]    [Pg.170]    [Pg.372]    [Pg.381]    [Pg.61]   
See also in sourсe #XX -- [ Pg.5 ]



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