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Site-specific drug delivery brain targeting

In conclusion, it may be clear that RMT and CMT are important processes for the influx and efflux of substances to and from the BBB endothelial compartment. Changed activity of these processes due to disease, for example, can have serious consequences for functionality and integrity of the BBB. On one hand, this can result in increased para- and transcellular BBB permeability, and therefore, in changed CNS homeostasis. Ultimately, this can lead to CNS diseases, e.g., Alzheimer s or other neurodegenerative diseases (25-27). On the other hand, this offers opportunities for site-specific or targeted drug delivery to the brain when transport processes are selectively upregulated under disease conditions. [Pg.635]

Khan, A. et al.. Site-specific administration of antisense oligonucleotides using biodegradable polymer microspheres provides sustained delivery and improved subcellular biodistribution in the neostriatum of the rat brain, /. Drug Target, 8,319,2000. [Pg.273]

See other pages where Site-specific drug delivery brain targeting is mentioned: [Pg.25]    [Pg.156]    [Pg.157]    [Pg.227]    [Pg.203]    [Pg.596]    [Pg.179]    [Pg.179]    [Pg.329]    [Pg.999]    [Pg.173]    [Pg.173]    [Pg.112]    [Pg.21]    [Pg.1112]    [Pg.160]    [Pg.205]    [Pg.544]    [Pg.90]    [Pg.216]    [Pg.14]    [Pg.78]    [Pg.5]    [Pg.153]    [Pg.151]    [Pg.349]    [Pg.694]    [Pg.694]   
See also in sourсe #XX -- [ Pg.835 ]

See also in sourсe #XX -- [ Pg.835 ]



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Brain delivery

Brain drug targeting

Brain specificity

Brain targeting

Drug brain

Drug delivery site-specific

Drugs targeting

Site specificity

Specific Drugs

Target site, specificity

Target sites

Target specifications

Target-specific

Targeted drugs

Targeting drug delivery

Targeting specificity

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