Target site, specificity

Craig NL. 1991. Tn7 a target site-specific transposon. Mol Microbiol 5 2569-73. 

Holmes-Son ML, Appa RS, Chow SA (2001), Molecular genetics and target site specificity of retroviral integration. Adv. Genet. 43 33-69. 

Yamamoto, H., Imamura, Y., Tagaya, M., Fukui, T Kawakita, M. (1989). Ca2+-dependent conformational change of the ATP-binding site of Ca2+-transporting ATPase of sarcoplasmic reticulum as revealed by an alteration of the target-site specificity of adenosine triphosphopyridoxal. J. Biochem. 106,1121-1125. 

The degree of target-site specificity of the reaction of R with GJPG can be characterized by the enhancement, E, which we will define as the ratio of the first-order rate constants for the specific and the bulk aggregate of the nonspecific reactions. That is,... 

Peptide egg exhibited considerable specificity for the CRE target site, approximately 75% that exhibited by ccc. The specificity of ccg was equal to that of ccc. Taken together, these results imply that the major determinants of CRE target site specificity exhibited by CRE-BPl reside within the basic segment. 

Selective toxicity conferred by target site specificity (e.g., biores-methrin) or metabolic degradation (lower toxicity for trans- than for cis-cyclopropanecarboxylates)... 

Moure CM, Gimble FS, Quiocho, F.A. (2003) The crystal sttucture of the gene targeting homing endonuclease 1-Scel reveals the origins of its target site specificity. J Mol Biol 334 685-695. 

Miyao, A., Tanaka, K., Murata, K., Sawaki, H., Takeda, S., Abe, K., Shinozuka, Y, Onosato, K., and Hirochika, H. 2003. Target site specificity of the Tosl 7 retrotransposon shows a preference for insertion within genes and against insertion in retrotransposon-rich regions of the genome. Plant Cell 15 1771-1780. 

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