Compliance site-specific drug delivery

Both the type of drug delivery system and the specific type of delivery device can affect drug absorption via the nasal route. The choice of delivery system depends mainly on the physiochemical properties of the drug, its desired site of action, and, more importantly, patient compliance and marketing aspects. The formulations most commonly used in nasal delivery are solutions, suspensions, gels, dry powders, and, most recently, nanoparticulate formulations. 

An efficient DDS must be capable of regulating the rate of release (delayed or extended-release systems] and/or targeting the drug to a specific site. An ideal DDS should provide a desired rate of delivery of the therapeutic dose, at the most appropriate place in the body, in order to prolong the duration of pharmacological action and reduce the adverse effects, minimize the dosing frequency and enhance patient compliance (Gong et al., 2008). 

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