Sarcoma renal cell

H. Other considerations Interferon alfa-2a has been designated an orphan drug product for the treatment of chronic myelogenous leukemia, AIDS-related Kaposi s sarcoma, renal cell carcinoma, metastatic malignant melanoma, and esophageal and colorectal cancer. 

Tumors exhibiting preferential spread to the lungs as the only site of metastasis include sarcoma, renal cell cancer, and head and neck cancer. In contrast, tumors such as breast, melanoma, and colorectal carcinoma typically metastasize to multiple organ sites (Davidson et al. 2001). 

Due to their biologic properties, a variety of other liver metastases may be resected with the prospect of the patient living 5 years or longer, and of being relieved of symptoms, i.e., due to hormonal secretion of neuroendocrine metastases. Selected isolated liver metastases from breast cancer, sarcoma, renal cell cancer and Wilms tumors, melanoma, other GI cancers, melanoma, and, most frequently, endocrine... 

Clinical trials showed therapeutic efficacy in a broad spectrum of tumors these include SCLC, testicular tumors, sarcomas, breast cancer, renal cell cancer, pancreatic tumors and lymphomas. Ifosfamide is less myelosuppressive than cyclophosphamide but is more toxic to the bladder. Therefore it is recommended that ifosfamide is coadministered with the thiol compound mesna to avoid hemorrhagic cystitis and to reduce the risk of developing bladder cancer. Other side effects include neurotoxicity and myelosuppression. 

Hairy cell leukaemia Renal cell carcinoma Basal cell carcinoma Malignant melanoma AIDS-related Kaposi s sarcoma Multiple myeloma Chronic myelogenous leukaemia Non-Hodgkin s lymphoma... 

As might be expected from a screen in which the target tumor was a soft tissue sarcoma, those tumors were among the most sensitive to the compound, along with ovarian tumors, mesotheliomas, melanomas, and lung carcinomas. Tumors least sensitive to this compound included pancreatic carcinomas, neuroblastomas, and especially, renal cell carcinomas. As a rule, for the seven classes of compounds identified in the screen, soft tissue sarcomas, ovarian carcinomas, and mesotheliomas were the most sensitive tumor types. 

WARNING Chemo agent handle w/ caution Uses Hodgkin Dz NHLs, mycosis fungoides, CAs (testis, renal cell, breast, NSCLC), AIDS-related Kaposi sarcoma, choriocarcinoma, histiocytosis Action X Microtubule assembly Dose 0.1-0.5 mg/kg/wk (4-20 mg/m ) X in hepatic failure Caution [D, ] Contra IT use Disp Inj SE i BM (esp leukopenia), NA, constipation, neurotox, alopecia, rash, myalgia, tumor pain Interactions T Effects W/ erythromycin, itraconazole X effects W/ glutamic acid, tryptophan X effects OF phenytoin EMS T Risk of... 

Unlabeled Uses Treatment of acquired immune deficiency syndrome (AlDS),AIDS-re-lated Kaposi s sarcoma, malignant melanoma, renal cell carcinoma... 

It is used for the treatment of non small cell lung carcinoma, breast carcinoma, Hodgkin s disease, ovarian carcinoma, squamous cell carcinoma of the head and neck, cervical squamous cell carcinoma, renal cell cancer and Kaposi s sarcoma. 

Several Type I and Type II interferons (IFN) and interleukin-2 (IL-2) have been approved to treat infectious diseases or malignancies by augmenting immune responses IFN-a2a (chronic hepatitis C) IFN-a2b (hepatitis C, melanoma, chronic myelogenous leukemia, hairy-cell leukemia, Kaposi s sarcoma, cutaneous T-cell lymphoma, renal cell carcinoma) IFN-aconl (chronic hepatitis C) IFN- 31a (multiple sclerosis) IFN-pib (multiple sclerosis) IFN-ylb (malignant osteopetrosis) and IL-2 (renal cell carcinoma). 

Chu P and Arber DA. Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms. Frequent expression in renal cell carcinoma and endometrial stromal sarcoma. Am J Clin Pathol 2000 113 374-82. 

Antibodies to these PEMs are directed to the apical membrane portions of secretory mammary cells surrounding milk fat globules (mol wt >250 kDa). They react with a variety of epithelial tumors, including mesotheliomas. Like keratin, these antibodies are also expressed on synovial sarcomas, epithelioid sarcomas, and chordomas. They are not as reactive with as wide a variety of tumors as antikeratins. For instance, they do not react with many endocrine tumors. However, they may recognize some renal-cell carcinomas and small-cell anaplastic carcinomas... 

Interferons. Interferon alfa is used for chronic granulocytic leukaemia, hairy cell leukaemia, renal-cell carcinoma and Kaposi s sarcoma. It may also be an effective aduvant therapy for patients at high risk of melanoma recurrence. 

Malignant diseases hairy cell leukemia, chronic myelogenous leukemia, cutaneous T cell lymphoma, follicular lymphoma, multiple myeloma, Kaposi s sarcoma, diffuse melanoma, renal cell carcinoma, carcinoid tumors Viral diseases condylomata acuminata, chronic active hepatitis B and C... 

Aldesleukin is indicated for the treatment of metastatic renal cell carcinoma in adults. It is also indicated for the treatment of metastatic melanoma in adults. Research is under way on the use of aldesleukin for the tieatmcni of various cancers (including head and neck cancers), treatmeni of acute myelogenous leukemia, and adjunct therapy in the treatment of Kapasi s sarcoma. Renal and hepatic Unction is typically impaired during therapy with aldesleukin, so interaction with other drugs that undergo elimination by these organs is po.ssible. 

Acute promyelocytic leukemia non-Hodgkin s lymphoma renal cell carcinoma Kaposi s sarcoma... 

IFNa) in leukemia, lymphoma, multiple myeloma, melanoma, renal cell carcinoma, and Kaposi s sarcoma. Side effects include flulike syndrome, fever, myalgias, rashes, thrombocytopenia, and neutropenia. ... 

CRA has been detected in humans [34] and was the first RAR-RXR pan-agonist discovered [35-37] and may be classified as a retinoid/rexinoid. It is the only retinoic acid isomer not approved for the common dermatological diseases. However, it has recently been launched in the US as adjuvant topical treatment of AIDS-associated Kaposi s sarcoma [38-41]. This agent is the first RXR ligand to be approved for the treatment of a dermatological disease. In a randomized study with 268 AIDS-associated Kaposi s sarcoma patients, 35% treated with alitretinoin (0.1% gel) had a positive response, compared with 18% treated with vehicle gel irrespective of the number of concurrent antiretroviral therapies [41], 9-CRA is in clinical trials for the treatment of various cancers, including breast cancer [42], renal cell carcinoma [43,44] and squamous cell carcinoma [45—47]. 

Zavala-Pompa A, Folpe AL, Jimenez RE, et al. Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and retroperitoneal sarcomas comparative evaluation with traditional diagnostic markers. Am J Surg Pathol. 2001 25 65-70. 

CD 10 is a marker of early lymphoid progenitor and normal germinal center cells. However, in the nonhe-matopoietic arena, it reacts mainly against proteins of the epithelium of the renal proximal tubule. It is considered a sensitive marker for renal cell carcinoma and endometrial stromal sarcomas. CD 10 stains some other... 

CD117 IN NONGIST LESIONS GDI 17 immunoreactivity is not restricted to GISTs and has been reported in a number of other neoplasms including melanoma, renal cell carcinoma, and seminoma.Sarcomas that have been reported to stain with c-kit include angiosarcoma, clear... 

IL-12 expresses reduced antitumor effects against B16F10 melanoma, M5076 reticulum cell sarcoma and Renca renal cell adenocarcinoma... 

Kamatsh and co-workers reported that growth of mouse sarcoma-37 cells incubated with aristolochic acid (5) at concentration of 100-200 pg/ml for 3 hours was completely inhibited. Treatment of mice with aristolochic acid (5) (1.25-5 mg/kg ip per day) for 3 days, after subcutaneous implantation of sarcoma-37 cells inhibited tumor growth by 40-50 %. The cytotoxicity on HeLa cells in culture was observed at concentration of 25 pg/ml [415]. The acute toxic effects of aristolochic acid I (5) were observed in rats and mice, oral or intravenous administration of high doses was followed by death from acute renal failure within 15 days [416], The biological activities of aristolochic acid I (5), aristolactam I... 

As the t(X 17)(pll.2 q25) translocation was not detected in any other soft tissue tumor, the molecular detection of the specific fusion transcripts can be used as an additional diagnostic assay to confirm the diagnosis of alveolar soft part sarcoma, however we have to consider that similar genetic abnormalities may be associated primary and metastatic papillary renal cell carcinoma. 

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