Carcinoma of lung

After metabolic activation, it depoly-merizes DNA and causes chromosomal damage and also nucleic acid synthesis inhibition. It is found to be effective in Hodgkin s disease and carcinoma of lungs. 

Etoposide Etopophos, VePesid Carcinoma of lung, testes Blood disorders (anemia, leukopenia, thrombocytopenia] Gl distress (nausea, vomiting] hypotension, allergic reactions hair loss neurotoxicity (peripheral neuropathies, CNS effects]... 

Carcinoma of lung Cisplatin plus taxane Methotrexate, vincristine, vinblastine, doxorubicin, mitomycin C... 

FIGURE 8.9 This sarcomatoid carcinoma of lung (A) richly coexpresses CAMS.2 (B) and vimentin (C) Most carcinomas of this type in lung and upper aerodigestive tract are sarcomatoid squamous cell carcinomas. 

Hanly AJ, Elgart GW, Jorda M, et al. Analysis of thyroid transcription factor-1 and cytokeratin 20 separates Merkel cell carcinoma from small cell carcinoma of lung. J Cutan Pathol. 2000 27 118-120. 

FIGURE 12.1 Nuclear p63 expression in a poorly differentiated squamous cell carcinoma of lung. X 100. 

FIGURE 12.5 This small cell carcinoma of lung shows intense nuclear immunostaining for thyroid transcription factor-1. X 200. 

FIGURE 12.6 Most small cell carcinomas of lung show punctate immunostaining for low molecular weight keratin. X 400. 

Immunohistochemical Features of Small Cell Squamous Carcinoma of Lung and Small Cell Neuroendocrine Carcinoma of Lung... 

FIGURE 12.32 This basaloid carcinoma of lung is composed of undifferentiated, relatively small cells and often resembles primary pulmonary neuroendocrine carcinomas. X 200. 

Cytokeratin Profiles of Epithelial Mesothelioma, Pulmonary Adenocarcinoma, and Squamous Cell Carcinoma of Lung ... 

Butler AE, Colby TV, Weiss L, et al. Lymphoepithelioma-like carcinoma of lung. Am J Surg Pathol. 1989 13 632-639. 

Robb JA, Hammar SP, Yokoo H. Pseudomesotheliomatous carcinoma of lung. Lab Invest. 1993 68 134A. 

Falconieri G, Zanconati F, Bussani R, et al. Small cell carcinoma of lung simttlating mesothelioma. Pathol Res Pract. 1995 191 1147-1151. 

Merchant SH, Amin MB, Tamboli P, et al. Primary signet-ring cell carcinoma of lung immunohistochemical study and comparison with non-pulmonary signet-ring cell carcinomas. Am J Surg Pathol. 2001 25 1515-1519. 

We ve seen already that inactivating mutations in both RB alleles lead to childhood retinoblastoma, a relatively rare type of cancer. However, loss of RB gene function also is found in more common cancers that arise later In life (e.g., carcinomas of lung, breast, and bladder). These tissues, unlike retinal tissue, most likely produce other proteins whose function is redundant with that of Rb, and thus loss of Rb is not so critical. Several proteins are known that are related in structure and probably function to Rb. In addition to inactivating mutations, Rb function can be eliminated by the binding of an inhibitory protein, designated E7, that is encoded by human papillomavirus (HPV), another nasty viral trick to create virus-producing tissue. 

Gastric adenocarcinoma, GIT carcinoids, islet pancreas tumors, mucinous adenocarcinomas of ovary, bronchoalveolar carcinomas of lung, adenocarcinomas of urinary bladder... 

Normal Primary EMIO Diploid and stable patient had epidermoid carcinoma of lung tissue used was from site remote from cancer... 

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