Lymphoid progenitors

Mixed myeloid progenitor cell Lymphoid progenitor cell... 

Ex vivo gene transfer into human lymphoid progenitors results in in vivo functionally mature transduced T- and -cells. Ficara, F., Aiuti, A., Mocchetti, C., Carballido, F., Superchi, D., Deola, S., Bordignon, C., Carballido, J., Roncarolo, M. 

Also known as the common ALL antigen, CDIO is a zinc metallopeptidase expressed in early lymphoid progenitors and normal germinal center cells. It is almost always present on the surface of precursor B lymphoblastic and Burkitt lymphomas, and much less frequently precursor T lymphoblastic leukemia/lym-phoma. Many FLs and some diffuse large B-cell lymphomas, along with multiple myeloma, are positive. CDIO and BCL-6 are commonly considered markers of germinal center origin (Fig. 6.10). 

CD 10 is a marker of early lymphoid progenitor and normal germinal center cells. However, in the nonhe-matopoietic arena, it reacts mainly against proteins of the epithelium of the renal proximal tubule. It is considered a sensitive marker for renal cell carcinoma and endometrial stromal sarcomas. CD 10 stains some other... 

Bone Marrow. It is very important to check multiple sites, such as the head of the femur, the shaft of the femur, and the vertebral bodies, as the amount of hematopoietic tissue in each of these sites is often different. Also, there are species differences in the relative proportion of fat to hematopoietic tissue that changes with age and location. Careful comparisons to age- and sex-matched control animals, and inherent species-specific degrees of normal variability are vital for making accurate statements concerning compound-induced changes. Also, since the bone marrow is a site of erythroid, as well as lymphoid progenitors, any alteration of cellularity needs identification of the cell type involved, if possible. 

Igarashi H, Medina KL, Yokota T. Early lymphoid progenitors in mouse and man are highly sensitive to glucocorticoids. Int Immunol 2005 17 501-511. 

There are accumulating evidences that the lymphoid lineages, consisting of B, T and natural killer cells, are generated from a common lymphoid progenitor by successive differentiation steps that are tightly controlled by various growth factors or cytokines as well as by the microenvironment. 

Kondo, M., Weissman, I.L., and Akashi, K., 1997, Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91 661-672. 

Common Myeloid Progenitors and Their Progeny Common Lymphoid Progenitors and Their Progeny Multipotent Cells... 

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