Soft-tissue tumors

Lloyd RD, Taylor GN, Angus W, et al. 1995. Soft tissue tumors in beagles injected with 241Am citrate. Health Phys 68(2) 225-233. 

Nga ME, Lim G-L, Barbro N, et al. Successful retrieval of fine-needle aspiration biopsy material from previously stained smears for immunocytochemistry a novel technique applied to three soft tissue tumors. Mod. Pathol. 2005 18 728-732. 

The alkylating agents can be considered to be cell-cycle independent drugs. They are used for the management of leukemias, lymphomas, multiple myeloma and some carcinoma s and soft tissue tumors, generally as components of drug combination regimens. Cyclophosphamide is also used for its marked immunosuppressant properties. 

What is the decay constant of gallium-67, a radioisotope used for imaging soft-tissue tumors The half-life... 

Graadt van Roggen, J. F., Bovee, J. V. M. G., Morreau, J., and Hogendoom, P. C. W. 1999. Diagnostic and prognostic implications of the unfolding molecular biology of bone and soft tissue tumors. 7. Clin. Pathol. 52 481 -89. 

Sreekantaiah, C., Ladanyi, M., Rodriguez, E., and Chaganti, R. S. K. 1994. Chromosomal aberrations in soft tissue tumors, relevance to diagnosis, classification, and molecular mechanisms. Am. J. Pathol. 144 1121-1134. 

S.A. Hynds, J. Welsh, J.M. Stewart, A. Jack, M. Soukop, C.S. McArdle, K.C. Caiman, C.P. Packard and J. Sheperd, Low-density lipoprotein metabolism in mice with soft tissue tumors, Biochem. Biophys. Acta 795 (1984) 589-595. 

Nielsen TO, West RB, Linn SC, Alter O, Knowling MA, O Connell IX, Zhu S, Eero M, Sherlock G, Pollack JR, Brown PO, Botstein D, Rijn Mvd. Molecular characterization of soft tissue tumors a gene expression stndy. Lancet 2002 359 1301-1307. 

The safety of gadodiamide-enhanced MRI in staging suspected or recurrent soft tissue tumors of the head and neck has been investigated in 48 patients (aged 37-86) (18). There was only one adverse event, moderate thirst. The authors concluded that the use of gadodiamide for MRI contrast-enhanced examination of the head and neck is safe and provides more diagnostic information than unenhanced images. 

Ekholm SE, Bjork-Eriksson T, Western A, NeUstrom H, Jonsson E, Johansson A, Lonn L, Mercke C, Tollesson PO. MRI staging using gadodiamide for soft-tissue tumors of the head and neck region. Results from a phase II trial and a 5-year clinical follow-up. Eur J Radiol 2001 39(3) 168-75. 

Biology of Antigens and Antibodies 83 Specific Soft Tissue Tumors 97... 

Antibody Reagents Used by the Authors in the Study of Soft Tissue Tumors... 

It must be stressed that CD56 and CD57 are not restricted to nerve sheath cells or neuroectodermal elements among all soft tissue tumors, but rather are most often observed in those cell types. Synovial sarcomas, LMSs, and some metastatic carcinomas also... 

The Wilms tumor-1 (WTl) gene is located on the short arm of chromosome 11 (llpl3). It encodes a protein that is a critical determinant of urogenital development and is expressed in >80% of nephroblastomas. With regard to osseous and soft tissue tumors, WTl protein is not a specific marker and is potentially present in angiosarcoma, malignant peripheral nerve sheath tumor, synovial sarcoma, osteosarcoma, myxoid liposarcoma, and clear-cell sarcoma.Nevertheless, it is most often utilized (in a structured panel with other immunodeter-minants) as an adjunctive indicator of endothelial differentiation in diagnostic practice. ... 

One of the greatest challenges in the realm of bone and soft tissue tumor pathology is the reliable recognition of osseous matrix production in malignant... 

Desmin is a specific marker for myogenic differentiation among soft tissue tumors, seen in almost all rhabdomyo-sarcomas/leiomyosarcomas, rhabdomyomas/leiomyomas. 

Vimentin is ubiquitous in soft tissue tumors, and is present in poorly differentiated sarcomas as the most primitive of cytoplasmic filaments. 

The perineurial cells in neurofibroma contain EMA, which may be detected immunohistochemically in a small population of cells in these tumors. EMA may also be of some value in the diagnosis of nerve sheath myxoma because of the existence of perineurial elements around most tumor lobules. Nerve sheath neoplasms are occasionally labeled by antibodies to GFAP, as are 50% of soft tissue myoepitheliomas, whereas other benign soft tissue tumors are not. Myelin basic protein may also be of some value in the diagnosis of schwann-ian tumors, although there has been some disagreement in the literature on this point. 

The potential presence of CD34 in diverse polygonal-cell soft tissue tumors, including epithelioid LMS, epithelioid MPNST, clear cell sarcoma, and epithelioid sarcoma, has diminished its potential utility as an indicator of endothelial differentiation." " We also have observed that epithelioid angiosarcomas may be reactive... 

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