Epithelial tumor

Scotton CJ, Wilson JL, Scott K, et al. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 2002 62 5930-5938. 

Recently, Polychronopoulou45 examined tobacco, ethanol, and coffee as risk factors for ovarian cancer in Greek women in a hospital-based case-control study with data collected from 1989 to 1991. Cases were 189 women who were residents of Greater Athens and less than 75 years old with histologically confirmed common malignant epithelial tumors of the ovary. Controls were female residents of Greater Athens, less than 75... 

Moch H, Kononen J, Kallioniemi OP, Sauter G (2001) Tissue microarrays what will they bring to molecular and anatomic pathology Adv Anat Pathol 8 14 20 Moll R (1998) Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors. Subcell Biochem 31 205 262... 

Many antibodies are available that react differentially to various epithelial tumors and thus are useful in estahlishing the tissue of origin. Following is a list of some of these antibodies and how they can be used to subclassily carcinomas. 

CEA is a heterogeneous glycoprotein of molecular weight 180,000 kDa. It was originally considered to be specific for colon carcinoma however, it is now known to be expressed in many different tumors and fetal tissues as well as adult colonic mucosa (27). Table 6 shows a summary of CEA reactivity in epithelial tumors. 

Most antibodies available are reactive with the core protein. The abnormal or decreased glycosylations characteristically seen in tumors unmasks epitopes on the core protein, giving rise to heterogeneous reactivity with different antibodies. To date, none of the antibodies directed to these antigens are specific for tumors or epithelial tumors of particular sites. 

Specific Antigens Expressed by Various Epithelial Tumors... 

As for HER-2, preclinical evidence exists to support targeting EGFR (HER-1) with a therapeutic intent in epithelial neoplasms. First, the expression of EGF receptors is elevated in many epithelial tumors and this overexpression has been associated with poor clinical outcome (28). Second, coexpression of high levels of EGFR and its ligands, EGF... 

Grarnpa G. 1967. Liver distribution of colloidal thorium dioxide and development of liver epithelial tumors in rats. Ann NY Acad Sci 145 738. 

PCNA—Proliferating cell nuclear antigen Breast carcinoma also in other epithelial tumors... 

Keding S J, Danishefsky S J. Prospects for total S3mthesis a vision for a totaUy synthetic vaccine targeting epithelial tumors. Proc Natl Acad Sci 2004 101 11937-11942. 

Adenoma. A benign epithelial tumor in which the cells form recognizable glandular structures or in which the cells are clearly derived from glandular epithelium. Adrenalectomize. To excise one or both adrenal glands. 

Vaccines generally used sialylated (s)Tn, which are mucin epitopes expressed on epithelial tumors, conjugated with KLH. This vaccine was commercialized as Theratope (Biomira Inc., Edmonton, Canada). In a phase I study O Boyle et al. [199] injected the vaccine to colorectal cancer patients. Toxicity was only local, and an antibody response was observed. 

ADCC antibody-dependent cell cytotoxicity, adenocarcinoma malignant epithelial tumor, adenoma benign epithelial tumor of glandular origin. 

Turusov, V.S., Lanko, N.S., Parfenov Y.D. Chemeris, GL (1990) 1,2-Dimethylhydrazine induction of epithelial tumors of the kidneys in CBA strain mice. Eksp. Onkol., 12,71-74 (in Russian)... 

Siegsmund et al. Renal epithelial tumor 212 Caucasian patients Susceptibility to renal tumor Higher in TTa... 

Siegsmund M, Brinkmann U, Schaffeler E, Weirich G, Schwab M, Eichel-baum M, Fritz P, Burk O, Decker J, Aiken P, Rothenpieler U, Kerb R, Hoff-meyer S, Brauch H. Association of the P-glycoprotein transporter MDR1 (C3435T) polymorphism with the susceptibility to renal epithelial tumors. J Am Soc Nephrol 2002 13 1847-1854. 

Caputo E, Lombardi ML, Luongo V, Moharram R, Tornatore P, Pirozzi G, et al. Peptide profiling in epithelial tumor plasma by the emerging proteomic techniques. J Chromatogr B Analyt Technol Biomed Life Sci 2005 819(1) 59—66. 

---