Parabens propylparaben

Aqua, glycerin, cyclopentasiloxane, ascorbic acid, propylene glycol, nylon-12, sodium citrate, dimethicone copolyol, acrylates copolymer, disodium EDTA, methyl paraben, propylparaben and parfum. 

Cosmetic Ingredient Review. 1984. Final report on the safety assessment of methylparaben, ethyl-paraben, propylparaben, andbutylparaben./. Amer. Col. Toxicol. 3 147-209. 

Preservatives. Most products must contain preservatives to ensure that yeasts, molds, and bacteria do not thrive in them. These preservatives include alcohol, methylparaben, propylparaben, DMDM hydantoin, diazohdinyl urea, and imidazohdinyl urea. The parabens have limited solubiUty in water, eg, 0.25% for methylparaben and 0.05% for propylparaben (22). If these levels are exceeded in the formula, then the addition of solvents is needed to ensure clear, stable products. 

Aqua, caprylic/capric triglyceride, Avene aqua, paraffinum liq-uidum, propylene glycol, glyceryl stearate, PEG-100 stearate, squa-lane, BHT, butyl paraben, C13-14 isoparaffin, carbomer, disodium EDTA, laureth-7, phenoxyethanol, polyacrylamide, propylparaben, Cl 17200, retinal, tocopheryl glucoside and triethanolamine. 

Parabens (methyl-, ethyl-, BUTYL-, AND PROPYLPARABEN) As a group, parabens are the most widely used cosmetic preservatives. They were banned in European cosmetics but are still allowed by the FDA. There is growing evidence that they mimic estrogen, which disrupts hormonal activity. A recent finding of high levels of parabens in breast tumors has spurred U.S. consumer protection groups to lobby the FDA against their use. 

Additional interactions between silica and neutral and acidic analytes have been observed [3,317,321]. One example is the resolution of methyl-paraben from propylparaben, benzoic acid, and famotidine [3]. Retention mechanism studies appear to show that interactions with the siloxane bridges are important [322]. 

Fig. 10.5. Separation of parabens with the poly(TBAAm-co-AMPS)-coated column. Conditions column, 750 mm x 25 pm i.d. (600 mm effective length) mobile phase, 20% acetonitrile (v/v) in 50 mMTris-HCl buffer field strength, 400 V/cm injection, 12 kV for 3 s at the side of the anode detection wavelength, 254 nm. Peak identification 1, methylparaben 2, ethylparaben 3, propylparaben 4, butylparaben 5, amylparaben. Reproduced with permission from Sawada and Jinno [11].

SYNS ASEPTOFORM P BETACIDE P BONOMOLD OP 4-HYDROXYBENZOIC ACID PROPYL ESTER p-HYDROXYBENZOIC ACID PROPYL ESTER NIPASOL p-OXYBENZOESAEUREPRO-PYLESTER (GERMAN) PARABEN PARj SEPT PASEPTOL PRESERVAL P PROPYL p-HYDROXY-BENZOATE n-PROP X p-HYDROXYBENZOATE PROPYLPARABEN (FCC) PROPYLPARASEPT PROTABEN P TEGOSEPT P... 

The activity of the parabens increases with increasing chain length of the alkyl moiety, but solubility decreases. Activity may be improved by using combinations of parabens since synergistic effects occur. Ethylparaben is commonly used with methylparaben and propylparaben in oral and topical formulations (such mixtures are commercially available for example, Nipasept (Nipa Laboratories Inc.). Activity has also been reported to be improved by the addition of other excipients see Methylparaben for further information. 

Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. Parabens, in vivo, have also been reported to exhibit estrogenic responses in fish. " ° The WHO has set an estimated total acceptable daily intake for methyl- ethyl-, and propylparabens at up to lOmg/kg body-weight. " " ... 

Methylparaben and propylparaben are affirmed GRAS Direct Food Substances in the USA at levels up to 0.1%. All esters except the benzyl ester are allowed for injection in Japan. In cosmetics, the EU and Brazil allow use of each paraben at 0.4%, but the total of all parabens may not exceed 0.8%. The upper limit in Japan is 1.0%. 

Propylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations. 

Propylparaben and methylparaben have been used as preservatives in injections and ophthalmic preparations however they are now generally regarded as being unsuitable for these types of formulations owing to the irritant potential of the parabens. 

The most frequently used antimicrobials found in commercial shampoos are parabens, methylparaben and propylparaben. Mixtures of different preservatives provide broader protection against a wider spectrum of microorganisms and have been proven to be the most effective method to ensure product robustness [100], The level of preservative necessary depends on the composition of ingredients, total alcohol level, pH value, and water activity. 

Preservatives Parabens (methylparaben, ethylparaben, butylparaben, propylparaben, etc.), EDTA, Formaldehyde, Quaternium 15, Methylisothiazolinone Skin irritation and allergic reactions. Can be neurotoxic. Some, like parabens, are suspected hormone disrupters. Also found in all cosmetics and toiletries. 

Paricin 13. See Glyceryl hydroxystearate Paricin 15. See Glycol hydroxystearate Paridoi B. See Butyl paraben Paridoi E. See Ethyl paraben Paridoi M. See Methyl paraben Paridoi P. See Propylparaben Parietaria officinalis Parietaria officinalis extract Parietary extract. SeePellitory (Parietaria officinalis) extract Paris green. See Copper acetoarsenite Paris red. See Lead oxide, red Paris violet. See Basic violet 1 Paris white. See Whiting Calcium carbonate Paris yellow. See Lead chromate Parlsey seed oleoresin. See Oleoresin parsley seed... 

Prepfos. See Pentasodium triphosphate Preserval B. See Benzyl paraben Preserval Butilique. See Butylparaben Preserval E. See Ethyl paraben Preserval M. See Methylparaben Preserval P. See Propylparaben Press-Aid SP] Press-Aid XP. See Synthetic wax... 

Tris (2,3-epoxypropyl) isocyanurate. See Triglycidyl isocyanurate Trisept B. See Butyl paraben Trisept E. See Ethylparaben Trisept M. See M ethyl paraben Trisept P. See Propylparaben Trisept SDHA. See Sodium dehydroacetate Tris (ethylenediamine) cadmium dihydroxide CAS 14874-24-9... 

Benzylparaben Potassium butyl paraben Potassium ethylparaben Potassium propylparaben Potassium sorbate... 

Lauramidopropyl PEG-dimonium chloride phosphate Lauroampho PEG-glycinate phosphate Potassium butyl paraben Potassium ethylparaben Potassium methyl paraben Potassium propylparaben Potassium sorbate Sodium butylparaben Sodium ethylparaben Sodium methylparaben Sodium propylparaben Sucrose myristate bactericide, photographic film Cocamidopropyl hydroxysultaine N,N-Dimethyl-N-lauric acid-amidopropyl-N-(3-sulfopropyl)-ammonium betaine N,N-Dimethyi-N-myristyi-N-(3-suifopropyi)-ammonium betaine N,N-Dimethyi-N-paimityi-N-(3-suifopropyi)-ammonium betaine N,N-Dimethyi-N-stearyi-N-(3-suifopropyi)-ammonium betaine... 

Benzylparaben Potassium butyl paraben Potassium ethylparaben Potassium propylparaben Sodium butylparaben Sodium ethylparaben Sodium methylparaben Sodium propionate Sodium propylparaben Sorbic acid Thiabendazole... 

Potassium propionate Potassium propylparaben Potassium salicylate Potassium sorbate Potassium sulfite Propionic acid Propyl benzoate Propylparaben Quatemium-15 Salicylic acid Silver borosilicate Silver chloride Silver magnesium aluminum phosphate Sodium benzoate Sodium bisulfite Sodium butylparaben Sodium dehydroacetate Sodium ethylparaben Sodium formate Sodium hydroxymethylglycinate Sodium iodate Sodium metabisulfite Sodium methylparaben Sodium paraben Sodium o-phenylphenate... 

Sodium 2-mercaptobenzothiazole Sodium pentachlorophenate Sodium o-phenylphenate Sodium salicylate Thymol Tributyltin acetate Tributyltin oxide Zinc dimethyidithiocarbamate Zinc 2-mercaptobenzothiazole preservative, food-packaging materials Methylparaben Propylparaben preservative, fruit drinks Heptyl paraben... 

Phenylmercuric borate Phenylmercuric nitrate Potassium benzoate Potassium bisulfite Potassium butyl paraben Potassium caroate Potassium ethylparaben Potassium lactate Potassium metabisulfite Potassium methylparaben Potassium propylparaben Potassium salicylate Potassium sorbate Potassium sulfite Propionic acid Propylene glycol Propyl gallate Propylparaben Salicylic acid Sodium ascorbate... 

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