Cosmetic Ingredient Review

Expert Panel of the Cosmetic Ingredient Review, Final Report on the Safety Assessment for Diisopropano/amine, Triisopropano/amine, Isopropano/amine, Mixed Isopropano/amines, Sept. 26, 1986 Final Report for the Safety Assessment for Triethanolamine, Diethanolamine, Monoethanolamine, May 19, 1983. 

Cosmetic Ingredient Review (1987) Final report on the safety assessment of retinyl palmitate and retinol. J Am Coll Toxicol 6 279-320... 

The genetic toxicity of diethanolamine has been reviewed by an expert panel for the cosmetic ingredient review (Beyer et al, 1983) and by Knaak et al (1997). 

Tentative Report of the Safety Assessment of Propylene Glycol, Cosmetic Ingredient Review, The Cosmetic, Toiletry, and Fragrance Association, Washington, D.C., 1992. 

Sodium Lauryl Sulfate (SLS) This substance makes everything from shampoo to bubble bath to toothpaste foam. The Cosmetic Ingredient Review (the industry experts who test the safety of ingredients) reported that it caused enough changes in mouse skin to warrant further study. The Environmental Working Group says avoid SLS whenever possible. 

Cosmetics Ingredients Review, http //www.ctfa-cir.org http //www.cir-safety.org/publications.shtml. 

Fiume MZ Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of biotin. Int J Toxicol 2001 20(Suppl 4) 1-12. 

Lecithin is a component of cell membranes and is therefore consumed as a normal part of the diet. Although excessive consumption may be harmful, it is highly biocompatible and oral doses of up to 80 g daily have been used therapeutically in the treatment of tardive dyskinesia. When used in topical formulations, lecithin is generally regarded as a nonirritant and nonsensitizing material. The Cosmetic Ingredients Review Expert Panel (CIR) has reviewed lecithin and issued a tentative report revising the safe concentration of the material from 1.95% to 15.0% in rinse-off and leave-in products. They note, however, that there are insufficient data to rule on products that are likely to be inhaled. ... 

Guidetti MS, Vincenzi C, Guerra L, Tosti A. Contact dermatitis due to oleyl alcohol. Contact Dermatitis 1994 31 260-261. CFTA. Final report on the safety assessment of stearyl alcohol, oleyl alcohol and octyl dodecanol. The Cosmetic Ingredient Review Program 1985 No. 4. 

Cosmetic Ingredients Review (CIR) (1983) Final report on the safety assessment of triethanolamine, diethanolamine, and monoethanolamine. Journal of the American College of Toxicology 2 183-235. 

Nair B, Elmore AR, and Cosmetic Ingredients Review Expert Panel. (2003) Final report on the safety assessment of sodium sulfite, potassium sulfite, ammonium sulfite, sodium bisulfite, ammonium bisulfite, sodium metabisulfite and potassium metabisulfite. International Journal of Toxicology 22(Suppl. 2) 63-88. 

Di- -butyl phthalate does not appear to be a skin sensitizer. A variety of cosmetic materials (e.g., deodorants, nail polish) containing 4.5-9% di- -butyl phthalate were not skin sensitizers when tested on 50-250 individuals per sample (Cosmetic Ingredient Review Committee 1985). In a 90-day study in rabbits, there was no indication that di- -butyl phthalate was a skin sensitizer (Lehman 1955). 

Program. The Cosmetic Ingredient Review was established in 1976 by the Cosmetic, Toiletry, Fragrance Association with snpport of the FDA and the Consnmer Federation of America. The Cosmetic Ingredient Review reviews and assesses the safety of ingredients used in cosmetics and publishes the results. 

There is an industry sponsored Cosmetic Ingredient Review (CIR) that tests the ingredients. Essentially, this is a self-regulated industry. 

MDS. 2000. MDS Pharma Services. Single dose toxicity study by the oral route in the rat. Unpublished data. In Bergfeld et al. 2004. Safety assessment of aloe. Cosmetic Ingredient Review. 

The Cosmetic Ingredient Review deemed calendula "safe as used" as a topical cosmetic product (CIR 2009). 

GIR. 2009. Cosmetic ingredients foimd safe as used. December 2009. Washington D.C. Cosmetic Ingredient Review. 

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